| Title: |
Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle |
| Authors: |
Castela, Mathieu; Linay, Fabien; Roy, Edwige; Moguelet, Philippe; Xu, Jie; Holzenberger, Martin; Khosrotehrani, Kiarash; Aractingi, Selim |
| Publisher Information: |
Wiley-Blackwell Publishing |
| Publication Year: |
2017 |
| Collection: |
The University of Queensland: UQ eSpace |
| Subject Terms: |
Anagen; Conditional gene targeting; Hair cycle; Igf1r; Stem cells; 1303 Biochemistry; 1312 Molecular Biology; 2708 Dermatology |
| Description: |
Insulin-like growth factor 1 (Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor (Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15-Igf1r mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15-Igf1r mice than in controls, without consequences on wound healing, at least in young mice. K15-Igf1r HFs entered anagen phase earlier than controls and showed a delay in the anagen/catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15-Igf1r. MED1 transcription was impaired in the epidermis of K15-Igf1r mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1600-0625; 0906-6705 |
| Relation: |
orcid:0000-0003-1991-5844; orcid:0000-0002-6406-4076; Not set |
| Availability: |
https://espace.library.uq.edu.au/view/UQ:682713 |
| Accession Number: |
edsbas.869E3929 |
| Database: |
BASE |