| Title: |
Analysis of shared heritability in common disorders of the brain |
| Authors: |
Anttila, V; Bulik-Sullivan, B; Finucane, HK; Walters, RK; Bras, J; Duncan, L; Escott-Price, V; Falcone, GJ; Gormley, P; Malik, R; Patsopoulos, NA; Ripke, S; Wei, Z; Yu, D; Lee, PH; Turley, P; Grenier-Boley, B; Chouraki, V; Kamatani, Y; Berr, C; Letenneur, L; Hannequin, D; Amouyel, P; Boland, A; Deleuze, J-F; Duron, E; Vardarajan, BN; Reitz, C; Goate, AM; Huentelman, MJ; Kamboh, MI; Larson, EB; Rogaeva, E; St George-Hyslop, P; Hakonarson, H; Kukull, WA; Farrer, LA; Barnes, LL; Beach, TG; Demirci, FY; Head, E; Hulette, CM; Jicha, GA; Kauwe, JSK; Kaye, JA; Leverenz, JB; Levey, AI; Lieberman, AP; Pankratz, VS; Poon, WW; Quinn, JF; Saykin, AJ; Schneider, LS; Smith, AG; Sonnen, JA; Stern, RA; Van Deerlin, VM; Van Eldik, LJ; Harold, D; Russo, G; Rubinsztein, DC; Bayer, A; Tsolaki, M; Proitsi, P; Fox, NC; Hampel, H; Owen, MJ; Mead, S; Passmore, P; Morgan, K; Noethen, MM; Rossor, M; Lupton, MK; Hoffmann, P; Kornhuber, J; Lawlor, B; McQuillin, A; Al-Chalabi, A; Bis, JC; Ruiz, A; Boada, M; Seshadri, S; Beiser, A; Rice, K; van der Lee, SJ; De Jager, PL; Geschwind, DH; Riemenschneider, M; Riedel-Heller, S; Rotter, JI; Ransmayr, G; Hyman, BT; Cruchaga, C; Alegret, M; Winsvold, B; Palta, P; Farh, K-H; Cuenca-Leon, E; Furlotte, N; Kurth, T; Ligthart, L; Terwindt, GM; Freilinger, T; Ran, C; Gordon, SD; Borck, G; Adams, HHH; Lehtimaki, T; Wedenoja, J; Buring, JE; Schuerks, M; Hrafnsdottir, M; Hottenga, J-J; Penninx, B; Artto, V; Kaunisto, M; Vepsalainen, S; Martin, NG; Montgomery, GW; Kurki, MI; Hamalainen, E; Huang, H; Huang, J; Sandor, C; Webber, C; Muller-Myhsok, B; Schreiber, S; Salomaa, V; Loehrer, E; Goebel, H; Macaya, A; Pozo-Rosich, P; Hansen, T; Werge, T; Kaprio, J; Metspalu, A; Kubisch, C; Ferrari, MD; Belin, AC; van den Maagdenberg, AMJM; Zwart, J-A; Boomsma, D; Eriksson, N; Olesen, J; Chasman, DI; Nyholt, DR; Avbersek, A; Baum, L; Berkovic, S; Bradfield, J; Buono, R; Catarino, CB; Cossette, P; De Jonghe, P; Depondt, C; Dlugos, D; Ferraro, TN; French, J; Hjalgrim, H; Jamnadas-Khoda, J; Kalviainen, R; Kunz, WS; Lerche, H; Leu, C; Lindhout, D; Lo, W; Lowenstein, D; McCormack, M; Moller, RS; Molloy, A; Ng, P-W; Oliver, K; Privitera, M; Radtke, R; Ruppert, A-K; Sander, T; Schachter, S; Schankin, C; Scheffer, I; Schoch, S; Sisodiya, SM; Smith, P; Sperling, M; Striano, P; Surges, R; Thomas, GN; Visscher, F; Whelan, CD; Zara, F; Heinzen, EL; Marson, A; Becker, F; Stroink, H; Zimprich, F; Gasser, T; Gibbs, R; Heutink, P; Martinez, M; Morris, HR; Sharma, M; Ryten, M; Mok, KY; Pulit, S; Bevan, S; Holliday, E; Attia, J; Battey, T; Boncoraglio, G; Thijs, V; Chen, W-M; Mitchell, B; Rothwell, P; Sharma, P; Sudlow, C; Vicente, A; Markus, H; Kourkoulis, C; Pera, J; Raffeld, M; Silliman, S; Perica, VB; Thornton, LM; Huckins, LM; Rayner, NW; Lewis, CM; Gratacos, M; Rybakowski, F; Keski-Rahkonen, A; Raevuori, A; Hudson, JI; Reichborn-Kjennerud, T; Monteleone, P; Karwautz, A; Mannik, K; Baker, JH; O'Toole, JK; Trace, SE; Davis, OSP; Helder, SG; Ehrlich, S; Herpertz-Dahlmann, B; Danner, UN; van Elburg, AA; Clementi, M; Forzan, M; Docampo, E; Lissowska, J; Hauser, J; Tortorella, A; Maj, M; Gonidakis, F; Tziouvas, K; Papezova, H; Yilmaz, Z; Wagner, G; Cohen-Woods, S; Herms, S; Julia, A; Rabionet, R; Dick, DM; Ripatti, S; Andreassen, OA; Espeseth, T; Lundervold, AJ; Steen, VM; Pinto, D; Scherer, SW; Aschauer, H; Schosser, A; Alfredsson, L; Padyukov, L; Halmi, KA; Mitchell, J; Strober, M; Bergen, AW; Kaye, W; Szatkiewicz, JP; Cormand, B; Antoni Ramos-Quiroga, J; Sanchez-Mora, C; Ribases, M; Casas, M; Hervas, A; Jesus Arranz, M; Haavik, J; Zayats, T; Johansson, S; Williams, N; Dempfle, A; Rothenberger, A; Kuntsi, J; Oades, RD; Banaschewski, T; Franke, B; Buitelaar, JK; Arias Vasquez, A; Doyle, AE; Reif, A; Lesch, K-P; Freitag, C; Rivero, O; Palmason, H; Romanos, M; Langley, K; Rietschel, M; Witt, SH; Dalsgaard, S; Borglum, AD; Waldman, I; Wilmot, B; Molly, N; Bau, CHD; Crosbie, J; Schachar, R; K., S; McGough, JJ; Grevet, EH; Medland, SE; Robinson, E; Weiss, LA; Bacchelli, E; Bailey, A; Bal, V; Battaglia, A; Betancur, C; Bolton, P; Cantor, R; Celestino-Soper, P; Dawson, G; De Rubeis, S; Duque, F; Green, A; Klauck, SM; Leboyer, M; Levitt, P; Maestrini, E; Mane, S; Moreno-De-Luca, D; Parr, J; Regan, R; Reichenberg, A; Sandin, S; Vorstman, J; Wassink, T; Wijsman, E; Cook, E; Santangelo, S; Delorme, R; Roge, B; Magalhaes, T; Arking, D; Schulze, TG; Thompson, RC; Strohmaier, J; Matthews, K; Melle, I; Morris, D; Blackwood, D; McIntosh, A; Bergen, SE; Schalling, M; Jamain, S; Maaser, A; Fischer, SB; Reinbold, CS; Fullerton, JM; Guzman-Parra, J; Mayoral, F; Schofield, PR; Cichon, S; Muhleisen, TW; Degenhardt, F; Schumacher, J; Bauer, M; Mitchell, PB; Gershon, ES; Rice, J; Potash, JB; Zandi, PP; Craddock, N; Ferrier, IN; Alda, M; Rouleau, GA; Turecki, G; Ophoff, R; Pato, C; Anjorin, A; Stahl, E; Leber, M; Czerski, PM; Cruceanu, C; Jones, IR; Posthuma, D; Andlauer, TFM; Forstner, AJ; Streit, F; Baune, BT; Air, T; Sinnamon, G; Wray, NR; MacIntyre, DJ; Porteous, D; Homuth, G; Rivera, M; Grove, J; Middeldorp, CM; Hickie, I; Pergadia, M; Mehta, D; Smit, JH; Jansen, R; de Geus, E; Dunn, E; Li, QS; Nauck, M; Schoevers, RA; Beekman, ATF; Knowles, JA; Viktorin, A; Arnold, P; Barr, CL; Bedoya-Berrio, G; Bienvenu, OJ; Brentani, H; Burton, C; Camarena, B; Cappi, C; Cath, D; Cavallini, M; Cusi, D; Darrow, S; Denys, D; Derks, EM; Dietrich, A; Fernandez, T; Figee, M; Freimer, N; Gerber, G; Grados, M; Greenberg, E; Hanna, GL; Hartmann, A; Hirschtritt, ME; Hoekstra, PJ; Huang, A; Huyser, C; Illmann, C; Jenike, M; Kuperman, S; Leventhal, B; Lochner, C; Lyon, GJ; Macciardi, F; Madruga-Garrido, M; Malaty, IA; Maras, A; McGrath, L; Miguel, EC; Mir, P; Nestadt, G; Nicolini, H; Okun, MS; Pakstis, A; Paschou, P; Piacentini, J; Pittenger, C; Plessen, K; Ramensky, V; Ramos, EM; Reus, V; Richter, MA; Riddle, MA; Robertson, MM; Roessner, V; Rosario, M; Samuels, JF; Sandor, P; Stein, DJ; Tsetsos, F; Van Nieuwerburgh, F; Weatherall, S; Wendland, JR; Wolanczyk, T; Worbe, Y; Zai, G; Goes, FS; McLaughlin, N; Nestadt, PS; Grabe, H-J; Depienne, C; Konkashbaev, A; Lanzagorta, N; Valencia-Duarte, A; Bramon, E; Buccola, N; Cahn, W; Cairns, M; Chong, SA; Cohen, D; Crespo-Facorro, B; Crowley, J; Davidson, M; DeLisi, L; Dinan, T; Donohoe, G; Drapeau, E; Duan, J; Haan, L; Hougaard, D; Karachanak-Yankova, S; Khrunin, A; Klovins, J; Kucinskas, V; Keong, JLC; Limborska, S; Loughland, C; Lonnqvist, J; Maher, B; Mattheisen, M; McDonald, C; Murphy, KC; Nenadic, I; van Os, J; Pantelis, C; Pato, M; Petryshen, T; Quested, D; Roussos, P; Sanders, AR; Schall, U; Schwab, SG; Sim, K; So, H-C; Stoegmann, E; Subramaniam, M; Toncheva, D; Waddington, J; Walters, J; Weiser, M; Cheng, W; Cloninger, R; Curtis, D; Gejman, PV; Henskens, F; Mattingsdal, M; Oh, S-Y; Scott, R; Webb, B; Breen, G; Churchhouse, C; Bulik, CM; Daly, M; Dichgans, M; Faraone, SV; Guerreiro, R; Holmans, P; Kendler, KS; Koeleman, B; Mathews, CA; Price, A; Scharf, J; Sklar, P; Williams, J; Wood, NW; Cotsapas, C; Palotie, A; Smoller, JW; Sullivan, P; Rosand, J; Corvin, A; Neale, BM |
| Source: |
Science , 360 (6395) , Article eaap8757. (2018) |
| Publisher Information: |
AMER ASSOC ADVANCEMENT SCIENCE |
| Publication Year: |
2018 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Science & Technology; Multidisciplinary Sciences; Science & Technology - Other Topics; GENOME-WIDE ASSOCIATION; DEFICIT HYPERACTIVITY DISORDER; MAJOR DEPRESSIVE DISORDER; POPULATION-BASED TWIN; LONG-TERM SURVIVAL; BODY-MASS INDEX; ALZHEIMERS-DISEASE; ANOREXIA-NERVOSA; BIPOLAR DISORDER; GENETIC CORRELATIONS |
| Description: |
Consistent classification of neuropsychiatric diseases is problematic because it can lead to misunderstanding of etiology. The Brainstorm Consortium examined multiple genome-wide association studies drawn from more than 200,000 patients for 25 brain-associated disorders and 17 phenotypes. Broadly, it appears that psychiatric and neurologic disorders share relatively little common genetic risk. However, different and independent pathways can result in similar clinical manifestations (e.g., psychosis, which occurs in both schizophrenia and Alzheimer's disease). Schizophrenia correlated with many psychiatric disorders, whereas the immunopathological affliction Crohn's disease did not, and posttraumatic stress syndrome was also largely independent of underlying traits. Essentially, the earlier the onset of a disorder, the more inheritable it appeared to be. Science, this issue p. eaap8757 |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10052781/1/Wood_aap8757_MainText.pdf; https://discovery.ucl.ac.uk/id/eprint/10052781/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10052781/1/Wood_aap8757_MainText.pdf; https://discovery.ucl.ac.uk/id/eprint/10052781/ |
| Rights: |
open |
| Accession Number: |
edsbas.86A55C4B |
| Database: |
BASE |