| Title: |
Clevidipine infusion for blood pressure management after successful revascularisation in acute ischaemic stroke: the CLEVER study |
| Authors: |
Jumaa, Mouhammad A; Gharaibeh, Khaled; Burgess, Richard E; Rao, Rahul; Oliver, Marion J; Mierzwa, Adam; Alhajala, Hisham S; Ali, Ashan; Jadhav, Ashutosh P; Castonguay, Alicia C; El-Sabae, Hijrah; Zaidi, Syed F |
| Contributors: |
Chiesi USA Inc. |
| Source: |
European Stroke Journal ; volume 11, issue 2 ; ISSN 2396-9873 2396-9881 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background Limited studies have provided guidance on the optimal systolic blood pressure (SBP) after mechanical thrombectomy (MT) in acute ischemic stroke patients. In the Clevidipine Infusion for Blood Pressure Management After Successful Revascularization in Acute Ischemic Stroke (CLEVER) trial, our aim was to study the safety and efficacy of intensive SBP control with a Clevidipine infusion as the first-line agent. Methods The CLEVER trial was an investigator-initiated, single-center, open-label, randomized, controlled trial. Patients were randomized 1:1 to a SBP goal after successful MT (mTICI 2c or greater) of either 90-120mmHg (Intensive BP Management) or 90-160mmHg (Standard BP Management). The primary outcomes were time to target blood pressure and incidence of any hemorrhagic conversion at 24 hours. Results Between October 2021 and December 2023, 80 eligible patients were enrolled, 40 each into the intensive BP and the standard BP management cohorts. Overall, 72% of all BP measurements in the intensive BP management group were within the target range, compared to 93% in the standard BP management group (p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/esj/aakag005 |
| Availability: |
https://doi.org/10.1093/esj/aakag005; https://academic.oup.com/esj/article-pdf/11/2/aakag005/66964491/aakag005.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.86C57563 |
| Database: |
BASE |