Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes:An IMI-DIRECT study
| Title: | Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes:An IMI-DIRECT study |
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| Authors: | Obura, Morgan; Beulens, Joline W. J.; Slieker, Roderick; Koopman, Anitra D. M.; Hoekstra, Trynke; Nijpels, Giel; Elders, Petra; Koivula, Robert W.; Kurbasic, Azra; Laakso, Markku; Hansen, Tue H.; Ridderstråle, Martin; Hansen, Torben; Pavo, Imre; Forgie, Ian; Jablonka, Bernd; Ruetten, Hartmut; Mari, Andrea; McCarthy, Mark I.; Walker, Mark; Heggie, Alison; McDonald, Timothy J.; Perry, Mandy H.; De Masi, Federico; Brunak, Søren; Mahajan, Anubha; Giordano, Giuseppe N.; Kokkola, Tarja; Dermitzakis, Emmanouil; Viñuela, Ana; Pedersen, Oluf; Schwenk, Jochen M.; Adamski, Jurek; Teare, Harriet J.A.; Pearson, Ewan R.; Franks, Paul W.; 't Hart, Leen M.; Rutters, Femke |
| Source: | Obura, M, Beulens, J W J, Slieker, R, Koopman, A D M, Hoekstra, T, Nijpels, G, Elders, P, Koivula, R W, Kurbasic, A, Laakso, M, Hansen, T H, Ridderstråle, M, Hansen, T, Pavo, I, Forgie, I, Jablonka, B, Ruetten, H, Mari, A, McCarthy, M I, Walker, M, Heggie, A, McDonald, T J, Perry, M H, De Masi, F, Brunak, S, Mahajan, A, Giordano, G N, Kokkola, T, Dermitzakis, E, Viñuela, A, Pedersen, O, Schwenk, J M, Adamski, J, Teare, H J A, Pearson, E R, Franks, P W, 't Hart, L M, Rutters, F & IMI DIRECT Consortium 2020, .... |
| Publication Year: | 2020 |
| Collection: | Discovery - University of Dundee Online Publications |
| Subject Terms: | /dk/atira/pure/subjectarea/asjc/1300/1300; name=General Biochemistry,Genetics and Molecular Biology; /dk/atira/pure/subjectarea/asjc/1100/1100; name=General Agricultural and Biological Sciences; /dk/atira/pure/subjectarea/asjc/1000; name=General |
| Description: | Aim : Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine the association between subgroups based on their glucose curves during a five-point mixed-meal tolerance test (MMT) and metabolic traits at baseline and glycaemic deterioration in individuals with T2D. Methods : The study included 787 individuals with newly diagnosed T2D from the Diabetes Research on Patient Stratification (IMI-DIRECT) Study. Latent class trajectory analysis (LCTA) was used to identify distinct glucose curve subgroups during a five-point MMT. Using general linear models, these subgroups were associated with metabolic traits at baseline and after 18 months of follow up, adjusted for potential confounders. Results : At baseline, we identified three glucose curve subgroups, labelled in order of increasing glucose peak levels as subgroup 1-3. Individuals in subgroup 2 and 3 were more likely to have higher levels of HbA1c, triglycerides and BMI at baseline, compared to those in subgroup 1. At 18 months (n = 651), the beta coefficients (95% CI) for change in HbA1c (mmol/mol) increased across subgroups with 0.37 (-0.18-1.92) for subgroup 2 and 1.88 (-0.08-3.85) for subgroup 3, relative to subgroup 1. The same trend was observed for change in levels of triglycerides and fasting glucose. Conclusions : Different glycaemic profiles with different metabolic traits and different degrees of subsequent glycaemic deterioration can be identified using data from a frequently sampled mixed-meal tolerance test in individuals with T2D. Subgroups with the highest peaks had greater metabolic risk. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | English |
| ISSN: | 1932-6203 |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/33253307; info:eu-repo/semantics/altIdentifier/pissn/1932-6203 |
| DOI: | 10.1371/journal.pone.0242360 |
| Availability: | https://discovery.dundee.ac.uk/en/publications/930a5979-1457-46c2-b58e-3a1533eca0c9; https://doi.org/10.1371/journal.pone.0242360; https://discovery.dundee.ac.uk/ws/files/55043127/journal.pone.0242360.pdf; https://www.scopus.com/pages/publications/85097034291 |
| Rights: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: | edsbas.86ECF31A |
| Database: | BASE |