| Title: |
Associations between neonatal hypoglycaemia and brain volumes, cortical thickness and white matter microstructure in mid-childhood: An MRI study |
| Authors: |
Nivins S; Kennedy E; Thompson B; Gamble GD; Alsweiler JM; Metcalfe R; McKinlay CJD; Harding JE |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2022 |
| Collection: |
University of Canterbury, Christchurch: UC Research Repository |
| Subject Terms: |
neonatal hypoglycaemia; MRI; Diffusion tensor imaging; brain volume; child; Fields of Research::32 - Biomedical and clinical sciences::3202 - Clinical sciences::320208 - Endocrinology; Fields of Research::32 - Biomedical and clinical sciences::3213 - Paediatrics::321303 - Neonatology; Fields of Research::32 - Biomedical and clinical sciences::3209 - Neurosciences |
| Description: |
Neonatal hypoglycaemia is a common metabolic disorder that may cause brain damage, most visible in parietooccipital regions on MRI in the acute phase. However, the long term effects of neonatal hypoglycaemia on the brain are not well understood. We investigated the association between neonatal hypoglycaemia and brain volumes, cortical thickness and white matter microstructure at 9–10 years. Children born at risk of neonatal hypoglycaemia at ≥ 36 weeks’ gestation who took part in a prospective cohort study underwent brain MRI at 9–10 years. Neonatal hypoglycaemia was defined as at least one hypoglycaemic episode (at least one consecutive blood glucose concentration < 2.6 mmol/L) or interstitial episode (at least 10 min of interstitial glucose concentrations < 2.6 mmol/L). Brain volumes and cortical thickness were computed using Freesurfer. White matter microstructure was assessed using tract-based spatial statistics. Children who had (n = 75) and had not (n = 26) experienced neonatal hypoglycaemia had similar combined parietal and occipital lobe volumes and no differences in white matter microstructure at nine years of age. However, those who had experienced neonatal hypoglycaemia had smaller caudate volumes (mean difference: − 557 mm3 , 95% confidence interval (CI), − 933 to − 182, p = 0.004) and smaller thalamus (− 0.03%, 95%CI, − 0.06 to 0.00; p = 0.05) and subcortical grey matter (− 0.10%, 95%CI − 0.20 to 0.00, p = 0.05) volumes as percentage of total brain volume, and thinner occipital lobe cortex (− 0.05 mm, 95%CI − 0.10 to 0.00, p = 0.05) than those who had not. The finding of smaller caudate volumes after neonatal hypoglycaemia was consistent across analyses of pre-specified severity groups, clinically detected hypoglycaemic episodes, and severity and frequency of hypoglycaemic events. Neonatal hypoglycaemia is associated with smaller deep grey matter brain regions and thinner occipital lobe cortex but not altered white matter microstructure in mid-childhood. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hdl.handle.net/10092/104322; http://doi.org/10.1016/j.nicl.2022.102943 |
| DOI: |
10.1016/j.nicl.2022.102943 |
| Availability: |
https://hdl.handle.net/10092/104322; https://doi.org/10.1016/j.nicl.2022.102943 |
| Rights: |
© 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). ; http://hdl.handle.net/10092/17651 |
| Accession Number: |
edsbas.87146B9F |
| Database: |
BASE |