| Title: |
Antitumor activity without on-target off-tumor toxicity of GD2–chimeric antigen receptor T cells in patients with neuroblastoma |
| Authors: |
Straathof, Karin; Flutter, Barry; Wallace, Rebecca; Jain, Neha; Loka, Thalia; Depani, Sarita; Wright, Gary; Thomas, Simon; Cheung, Gordon Weng-Kit; Gileadi, Talia; Stafford, Sian; Kokalaki, Evangelia; Barton, Jack; Marriott, Clare; Rampling, Dyanne; Ogunbiyi, Olumide; Akarca, Ayse U.; Marafioti, Teresa; Inglott, Sarah; Gilmour, Kimberly; Al-Hajj, Muhammad; Day, William; McHugh, Kieran; Biassoni, Lorenzo; Sizer, Natalie; Barton, Claire; Edwards, David; Dragoni, Ilaria; Silvester, Julie; Dyer, Karen; Traub, Stephanie; Elson, Lily; Brook, Sue; Westwood, Nigel; Robson, Lesley; Bedi, Ami; Howe, Karen; Barry, Ailish; Duncan, Catriona; Barone, Giuseppe; Pule, Martin; Anderson, John |
| Contributors: |
Wellcome; Cancer Research UK; Action Medical Research; Great Ormond Street Hospital Charity; Neuroblastoma UK; Research in Childhood Cancer; NIHR Great Ormond Street Biomedical Research Centre |
| Source: |
Science Translational Medicine ; volume 12, issue 571 ; ISSN 1946-6234 1946-6242 |
| Publisher Information: |
American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2020 |
| Description: |
Patients with neuroblastoma infused with GD2-directed CAR-T cells experienced immune activation and transient tumor regressions without neurotoxicity. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1126/scitranslmed.abd6169 |
| Availability: |
https://doi.org/10.1126/scitranslmed.abd6169; https://syndication.highwire.org/content/doi/10.1126/scitranslmed.abd6169; https://www.science.org/doi/pdf/10.1126/scitranslmed.abd6169 |
| Accession Number: |
edsbas.876A66BA |
| Database: |
BASE |