| Title: |
Identification of common variants associated with human hippocampal and intracranial volumes. |
| Authors: |
Stein, Jason L; Medland, Sarah E; Bernard, Manon; Nauck, Matthias; Nöthen, Markus M.; Olvera, Rene L; Pandolfo, Massimo; Pike, G Bruce; Puls, Ralf; Reinvang, Ivar; Rentería, Miguel E; Rietschel, Marcella; Roffman, Joshua L; Brown, Andrew A; Royle, Natalie A; Rujescu, Dan; Savitz, Jonathan; Schnack, Hugo G; Schnell, Knut; Seiferth, Nina; Smith, Colin; Steen, Vidar M; Valdés Hernández, Maria C; Van den Heuvel, Martijn; Cannon, Dara M; van der Wee, Nic J; Van Haren, Neeltje E M; Veltman, Joris A; Völzke, Henry; Walker, Robert; Westlye, Lars T; Whelan, Christopher D; Agartz, Ingrid; Boomsma, Dorret I; Cavalleri, Gianpiero L; Chakravarty, M Mallar; Dale, Anders M; Djurovic, Srdjan; Drevets, Wayne C; Hagoort, Peter; Hall, Jeremy; Heinz, Andreas; Jack, Clifford R; Foroud, Tatiana M; Le Hellard, Stephanie; Macciardi, Fabio; Christoforou, Andrea; Montgomery, Grant W; Poline, Jean Baptiste; Porteous, David J; Sisodiya, Sanjay M; Starr, John M; Sussmann, Jessika; Toga, Arthur W; Veltman, Dick J; Walter, Henrik; Weiner, Michael W; Domin, Martin; Initiative, Alzheimer's Disease Neuroimaging; Consortium, EPIGEN; Consortium, IMAGEN; Group, Saguenay Youth Study; Bis, Joshua C; Ikram, M Arfan; Smith, Albert V; Gudnason, Vilmundur; Tzourio, Christophe; Vernooij, Meike W; Grimm, Oliver; Launer, Lenore J; DeCarli, Charles; Seshadri, Sudha; Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology; Andreassen, Ole A; Apostolova, Liana G; Bastin, Mark E; Blangero, John; Brunner, Han G; Buckner, Randy L; Hollinshead, Marisa; Cichon, Sven; Coppola, Giovanni; de Zubicaray, Greig I; Deary, Ian J; Donohoe, Gary; de Geus, Eco J C; Espeseth, Thomas; Fernández, Guillén; Glahn, David C; Grabe, Hans J; Holmes, Avram J; Hardy, John; Hulshoff Pol, Hilleke E; Jenkinson, Mark; Kahn, René S; McDonald, Colm; McIntosh, Andrew M; McMahon, Francis J; McMahon, Katie L; Meyer-Lindenberg, Andreas; Morris, Derek W; Homuth, Georg; Müller-Myhsok, Bertram; Nichols, Thomas E; Ophoff, Roel A; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W; Potkin, Steven G; Sämann, Philipp G; Saykin, Andrew J; Schumann, Gunter; Vasquez, Alejandro Arias; Hottenga, Jouke-Jan; Smoller, Jordan W; Wardlaw, Joanna M; Weale, Michael E; Martin, Nicholas G; Franke, Barbara; Wright, Margaret J; Thompson, Paul M; Consortium, Enhancing Neuro Imaging Genetics through Meta-Analysis; Weiner, Michael; Aisen, Paul; Langan, Camilla; Petersen, Ronald; Jagust, William; Trojanowki, John Q; Beckett, Laurel; Green, Robert C; Morris, John; Liu, Enchi; Lopez, Lorna M; Montine, Tom; Gamst, Anthony; Thomas, Ronald G; Donohue, Michael; Walter, Sarah; Gessert, Devon; Sather, Tamie; Hansell, Narelle K; Harvey, Danielle; Kornak, John; Dale, Anders; Bernstein, Matthew; Felmlee, Joel; Fox, Nick; Hwang, Kristy S; Thompson, Paul; Schuff, Norbert; Alexander, Gene; Bandy, Dan; Koeppe, Robert A; Foster, Norm; Reiman, Eric M; Chen, Kewei; Mathis, Chet; Kim, Sungeun; Cairns, Nigel J; Taylor-Reinwald, Lisa; Trojanowki, J. Q.; Shaw, Les; Lee, Virginia M Y; Korecka, Magdalena; Crawford, Karen; Neu, Scott; Laje, Gonzalo; Potkin, Steven; Shen, Li; Kachaturian, Zaven; Frank, Richard; Snyder, Peter J; Molchan, Susan; Kaye, Jeffrey; Quinn, Joseph; Lee, Phil H; Lind, Betty; Dolen, Sara; Schneider, Lon S; Pawluczyk, Sonia; Spann, Bryan M; Brewer, James; Vanderswag, Helen; Heidebrink, Judith L; Lord, Joanne L; Liu, Xinmin; Johnson, Kris; Doody, Rachelle S; Villanueva-Meyer, Javier; Chowdhury, Munir; Stern, Yaakov; Honig, Lawrence S; Bell, Karen L; Morris, John C; Ances, Beau; Carroll, Maria; Loth, Eva; Leon, Sue; Mintun, Mark A; Schneider, Stacy; Marson, Daniel; Griffith, Randall; Clark, David; Grossman, Hillel; Mitsis, Effie; Romirowsky, Aliza; deToledo-Morrell, Leyla; Hibar, Derrek P; Lourdusamy, Anbarasu; Shah, Raj C; Duara, Ranjan; Varon, Daniel; Roberts, Peggy; Albert, Marilyn; Onyike, Chiadi; Kielb, Stephanie; Rusinek, Henry; de Leon, Mony J; Glodzik, Lidia; Mattingsdal, Morten; De Santi, Susan; Doraiswamy, P Murali; Petrella, Jeffrey R; Coleman, R Edward; Arnold, Steven E; Karlawish, Jason H; Wolk, David; Smith, Charles D; Jicha, Greg; Hardy, Peter; Mohnke, Sebastian; Lopez, Oscar L; Oakley, MaryAnn; Simpson, Donna M; Porsteinsson, Anton P; Goldstein, Bonnie S; Martin, Kim; Makino, Kelly M; Ismail, M Saleem; Mulnard, Ruth A; Thai, Gaby; Maniega, Susana Muñoz; Mc-Adams-Ortiz, Catherine; Womack, Kyle; Mathews, Dana; Quiceno, Mary; Diaz-Arrastia, Ramon; King, Richard; Weiner, Myron; Martin-Cook, Kristen; DeVous, Michael; Levey, Allan I; Nho, Kwangsik; Lah, James J; Cellar, Janet S; Burns, Jeffrey M; Anderson, Heather S; Swerdlow, Russell H; Apostolova, Liana; Lu, Po H; Bartzokis, George; Silverman, Daniel H S; Graff-Radford, Neill R; Nugent, Allison C; Parfitt, Francine; Johnson, Heather; Farlow, Martin R; Hake, Ann Marie; Matthews, Brandy R; Herring, Scott; van Dyck, Christopher H; Carson, Richard E; MacAvoy, Martha G; Chertkow, Howard; O'Brien, Carol; Bergman, Howard; Hosei, Chris; Black, Sandra; Stefanovic, Bojana; Caldwell, Curtis; Hsiung, Ging-Yuek Robin; Feldman, Howard; Mudge, Benita; Assaly, Michele; Kertesz, Andrew; Papmeyer, Martina; Rogers, John; Trost, Dick; Bernick, Charles; Munic, Donna; Kerwin, Diana; Mesulam, Marek-Marsel; Lipowski, Kristina; Wu, Chuang-Kuo; Johnson, Nancy; Sadowsky, Carl; Pütz, Benno; Martinez, Walter; Villena, Teresa; Turner, Raymond Scott; Johnson, Kathleen; Reynolds, Brigid; Sperling, Reisa A; Johnson, Keith A; Marshall, Gad; Frey, Meghan; Yesavage, Jerome; Ramasamy, Adaikalavan; Taylor, Joy L; Lane, Barton; Rosen, Allyson; Tinklenberg, Jared; Sabbagh, Marwan; Belden, Christine; Jacobson, Sandra; Kowall, Neil; Killiany, Ronald; Budson, Andrew E; Senstad, Rudy E; Rasmussen, Jerod; Norbash, Alexander; Johnson, Patricia Lynn; Obisesan, Thomas O; Wolday, Saba; Bwayo, Salome K; Lerner, Alan; Hudson, Leon; Ogrocki, Paula; Fletcher, Evan; Carmichael, Owen; Rijpkema, Mark; Olichney, John; Kittur, Smita; Borrie, Michael; Lee, T-Y; Bartha, Rob; Johnson, Sterling; Asthana, Sanjay; Carlsson, Cynthia M; Risacher, Shannon L; Preda, Adrian; Nguyen, Dana; Tariot, Pierre; Fleisher, Adam; Reeder, Stephanie; Bates, Vernice; Capote, Horacio; Rainka, Michelle; Scharre, Douglas W; Kataki, Maria; Roddey, J Cooper; Zimmerman, Earl A; Celmins, Dzintra; Brown, Alice D; Pearlson, Godfrey D; Blank, Karen; Anderson, Karen; Santulli, Robert B; Schwartz, Eben S; Sink, Kaycee M; Rose, Emma J; Williamson, Jeff D; Garg, Pradeep; Watkins, Franklin; Ott, Brian R; Querfurth, Henry; Tremont, Geoffrey; Salloway, Stephen; Malloy, Paul; Correia, Stephen; Rosen, Howard J; Ryten, Mina; Miller, Bruce L; Mintzer, Jacobo; Longmire, Crystal Flynn; Spicer, Kenneth; Finger, Elizabeth; Rachinsky, Irina; Drost, Dick; Cavalleri, Gianpiero; Alhusaini, Saud; Delanty, Norman; Whelan, Christopher; Sisodiya, Sanjay; Kasperaviciute, Dalia; Matarin, Mar; Depondt, Chantal; Goldstein, David B; Heinzen, Erin L; Shianna, Kevin; Sprooten, Emma; Radtke, Rodney; Ottmann, Ruth; Sergievsky, G. H.; Schumann, G.; Conrod, P.; Reed, L.; Barker, G.; Williams, S.; Loth, E.; Struve, M.; Strengman, Eric; Lourdusamy, A.; Cattrell, A.; Nymberg, C.; Topper, L.; Smith, L.; Havatzias, S.; Stueber, K.; Mallik, C.; Stacey, D.; Wong, C Peng; Teumer, Alexander; Werts, H.; Andrew, C.; Desrivieres, S.; Heinz, A.; Gallinat, J.; Häke, I.; Ivanov, N.; Klär, A.; Reuter, J.; Winkler, Anderson M; Trabzuni, Daniah; Palafox, C.; Hohmann, C.; Schilling, C.; Lüdemann, K.; Romanowski, A.; Ströhle, A.; Wolff, E.; Rapp, M.; Ittermann, B.; Brühl, R.; Turner, Jessica; Ihlenfeld, A.; Walaszek, B.; Schubert, F.; Garavan, H.; Connolly, C.; Jones, J.; Lalor, E.; McCabe, E.; Ní Shiothcháin, A.; Whelan, R.; van Eijk, Kristel; Spanagel, R.; Leonardi-Essmann, F.; Sommer, W.; Flor, H.; Vollstaedt-Klein, S.; Nees, F.; Banaschewski, T.; Poustka, L.; Steiner, S.; Mann, K.; van Erp, Theo G M; Buehler, M.; Rietschel, M.; Stolzenburg, E.; Schmal, C.; Schirmbeck, F.; Paus, T.; Gowland, P.; Heym, N.; Lawrence, C.; Newman, C.; van Tol, Marie-Jose; Pausova, Z.; Smolka, M.; Huebner, T.; Ripke, S.; Mennigen, E.; Muller, K.; Ziesch, V.; Büchel, C.; Bromberg, U.; Fadai, T.; Wittfeld, Katharina; Lueken, L.; Yacubian, J.; Finsterbusch, J.; Martinot, J. L.; Artiges, E.; Bordas, N.; de Bournonville, S.; Bricaud, Z.; Gollier Briand, F.; Lemaitre, H.; Wolf, Christiane; Massicotte, J.; Miranda, R.; Paillère Martinot, M. L.; Penttilä, J.; Poline, J. B.; Barbot, A.; Schwartz, Y.; Lalanne, C.; Frouin, V.; Thyreau, B.; Woudstra, Saskia; Dalley, J.; Mar, A.; Robbins, T.; Subramaniam, N.; Theobald, D.; Richmond, N.; de Rover, M.; Molander, A.; Jordan, E.; Robinson, E.; Aleman, Andre; Hipolata, L.; Moreno, M.; Arroyo, M.; Stephens, D.; Ripley, T.; Crombag, H.; Pena, Y.; Lathrop, M.; Zelenika, D.; Heath, S.; Lanzerath, D.; Heinrichs, B.; Spranger, T.; Fuchs, B.; Speiser, C.; Resch, F.; Haffner, J.; Parzer, P.; Brunner, R.; Klaassen, A.; Toro, Roberto; Almasy, Laura; Klaassen, I.; Constant, P.; Mignon, X.; Thomsen, T.; Zysset, S.; Vestboe, A.; Ireland, J.; Rogers, J.; Binder, Elisabeth B; Chakravarty, Mallar; Smith, Albert Vernon; van der Lijn, Fedde; Crivello, Fabrice; Fornage, Myriam; Shulman, Joshua M; Brohawn, David G; Schmidt, Helena; Srikanth, Velandai; Schuur, Maaike; Yu, Lei; Choi, Seung-Hoan; Sigurdsson, Sigurdur; Verhaaren, Benjamin F J; DeStefano, Anita L; Lambert, Jean-Charles; Cantor, Rita M; Struchalin, Maksim; Stankovich, Jim; Ibrahim-Verbaas, Carla A; Fleischman, Debra; Zijdenbos, Alex; den Heijer, Tom; Mazoyer, Bernard; Coker, Laura H; Enzinger, Christian; Danoy, Patrick; Carless, Melanie A; Amin, Najaf; Arfanakis, Konstantinos; van Buchem, Mark A; de Bruijn, Renée F A G; Beiser, Alexa; Dufouil, Carole; Huang, Juebin; Cavalieri, Margherita; Thomson, Russell; Niessen, Wiro J; Corvin, Aiden; Chibnik, Lori B; Gislason, Gauti K; Hofman, Albert; Pikula, Aleksandra; Amouyel, Philippe; Freeman, Kevin B; Phan, Thanh G; Oostra, Ben A; Nalls, Michael A; Uitterlinden, Andre G; Czisch, Michael; Au, Rhoda; Elbaz, Alexis; Beare, Richard J; van Swieten, John C; Lopez, Oscar; Harris, Tamara B; Chouraki, Vincent; Breteler, Monique M B; De Jager, Philip L; Becker, James T; Curran, Joanne E; Knopman, David; Fazekas, Franz; Wolf, Philip A; van der Lugt, Aad; Longstreth, W. T.; Brown, Mathew A; Bennett, David A; van Duijn, Cornelia M; Davies, Gail; Mosley, Thomas H; Schmidt, Reinhold; de Almeida, Marcio A A; Appel, Katja; Duggirala, Ravi; Dyer, Thomas D; Erk, Susanne; Fagerness, Jesen; Fox, Peter T; Freimer, Nelson B; Gill, Michael; Göring, Harald H H; Bartecek, Richard; Hagler, Donald J; Hoehn, David; Holsboer, Florian; Hoogman, Martine; Hosten, Norbert; Jahanshad, Neda; Johnson, Matthew P; Kent, Jack W; Kochunov, Peter; Bergmann, Ørjan; Lancaster, Jack L; Lawrie, Stephen M; Liewald, David C; Mandl, René; Mattheisen, Manuel; Meisenzahl, Eva; Melle, Ingrid; Moses, Eric K; Mühleisen, Thomas W |
| Source: |
Nature genetics 44(5), 552-561 (2012). doi:10.1038/ng.2250 |
| Publisher Information: |
Macmillan Publishers Limited, part of Springer Nature |
| Publication Year: |
2012 |
| Subject Terms: |
info:eu-repo/classification/ddc/570; Brain: physiopathology; Chromosomes; Human; Pair 12: genetics; Genetic Loci; Genetic Markers; Genome-Wide Association Study; Hippocampus: physiopathology; Humans; Meta-Analysis as Topic; Neuroimaging; Polymorphism; Single Nucleotide: genetics |
| Subject Geographic: |
DE |
| Description: |
Identifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease and is reduced in schizophrenia, major depression and mesial temporal lobe epilepsy. Whereas many brain imaging phenotypes are highly heritable, identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 × 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 × 10(-7)). |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1546-1718; 1061-4036 |
| Relation: |
info:eu-repo/semantics/altIdentifier/issn/1546-1718; info:eu-repo/semantics/altIdentifier/issn/1061-4036; info:eu-repo/semantics/altIdentifier/pmid/pmid:22504417; https://pub.dzne.de/record/136506 |
| Availability: |
https://pub.dzne.de/record/136506; https://pub.dzne.de/search?p=id:%22DZNE-2020-02828%22 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.87A34BA0 |
| Database: |
BASE |