| Title: |
Fatigue levels and associated factors in systemic sclerosis: a cross-sectional study of 2385 SPIN Cohort participants |
| Authors: |
Kwakkenbos, Linda; Levis, Brooke; Henry, Richard S; Virgili-Gervais, Gabrielle; Carrier, Marie-Eve; Bartlett, S. J.; Gietzen, A.; Gottesman, K.; Guillot, G.; Lawrie-Jones, A.; Hummers, L. K.; Malcarne, V. L.; Mayes, M. D.; Richard, M.; Wojeck, R. K.; Worron-Sauvé, M.; Hudson, M.; Mouthon, L.; Benedetti, A.; Thombs, B. D.; Adams, C. E.; El-Baalbaki, G.; Fligelstone, K.; Frech, T.; Harel, D.; Hinchcliff, M.; Johnson, S. R.; Larche, M.; Leite, C.; Nguyen, C.; Nielsen, K.; Pope, J.; Rannou, F.; Rodriguez-Reyna, T. S.; Schouffoer, A. A.; Suarez-Almazor, M. E.; Agard, C.; Alric, L.; Andre, M.; Beaslay, F.; Bernstein, E. J.; Berthier, S.; Bissonnette, L.; Blaise, S.; Bories, E.; Bruns, A.; Cacciatore, C.; Carreira, P.; Casadevall, M.; Chaigne, B.; Chung, L. R. D.; Crichi, B.; Deltombe, T.; Denton, C.; Desroche, T.; Domsic, R.; Dunne, J.; Dunogue, B.; Fare, R.; Farge-Bancel, D.; Fortin, P. R.; Gauzere, L.; Gerber, A.; Gordon, J. K.; Granel-Rey, B.; Guffroy, A.; Gyger, G.; Hachulla, E.; Hoa, S.; Hughes, M.; Ikic, A.; Khalidi, N.; Lakin, K. S.; Lambert, Marc; Launay, David; Lee, Y. C.; Legendre, P.; Maillard, H.; Maltez, N.; Manning, J.; Marie, I.; Lopez, M. M.; Martin, T.; Masetto, A.; Mekinian, A.; Diaz, S. M.; Mourguet, M.; Nikpour, M.; Olagne, L.; Poindron, V.; Proudman, S.; Pugnet, G.; Raffray, L.; Regent, A.; Renou, F.; Riviere, S.; Robinson, D.; Almazar, E. R.; Roux, S.; Smets, P.; Sobanski, V.; Spiera, R. F.; Steen, V.; Sutton, E.; Thorne, C.; Vagner, D.; Varga, J.; Wilcox, P.; Ayala, M. C.; Cook, V.; Santo, C. D.; Dal Santo, T.; D'onofrio, M.; Hu, S. P.; Nassar, E. L.; Neyer, M. A.; Provencher, S. |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Radboud University Nijmegen; Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 RID-AGE; Institute for Translational Research in Inflammation - U 1286 INFINITE |
| Publisher Information: |
Oxford Academic |
| Publication Year: |
2025 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Description: |
Objectives The objectives of this study were to compare fatigue in a large multinational SSc cohort with general population data and identify associated sociodemographic, lifestyle and SSc disease factors. Methods Scleroderma Patient-centered Intervention Network Cohort participants completed the Patient-Reported Outcomes Measurement Information System-29 v2.0 fatigue domain. T-scores were compared with the USA general population (mean = 50; s.d. = 10). Multivariable linear regression was used to assess associations with sociodemographic, lifestyle, and disease-related variables. Results Among the 2385 participants [mean age 54.9 (s.d. = 12.6) years, 87% female, 38% dcSSc], the mean fatigue T-score was 54.6 (s.d. = 11.0); 438 (18%) reported mild fatigue, 641 (27%) moderate fatigue, and 180 (8%) severe fatigue. Fatigue was independently associated with sociodemographic factors age [−0.10 points per year, (95% CI −0.14, −0.07)], male sex [−1.67 points, (−2.96, −0.37)], non-married status [0.97 points (0.04, 1.89)] and country [reference USA; France −2.35 points (−3.48, −1.21) and UK 2.38 points (0.80, 3.97)], and lifestyle factors smoking [4.16 points (2.52, 5.80)], alcohol consumption [−0.18 points per drink per week (−0.28, −0.07)] and BMI [0.34 points per unit (0.27, 0.42)]. Fatigue was associated with disease-related factors, including gastrointestinal involvement [4.21 points (2.99, 5.43)], digital ulcers [1.51 points, (0.25, 2.77)], moderate small joint contractures (1.41 points [0.13, 2.69]), RA [4.34 points (2.37, 6.31)] and SS [1.89 points (0.23, 3.55)]. When pain was included in the model, its association was large [2.19 points (2.03, 2.34)], and interstitial lung disease was also associated [1.21 points (0.42, 2.00)]. Conclusion In people with SSc, fatigue scores were substantially higher than in the general population and associated with multiple disease factors, including gastrointestinal involvement, several painful disease manifestations, and lung involvement. ; 64;5 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream; application/rdf+xml; charset=utf-8 |
| Language: |
English |
| Relation: |
Rheumatology |
| Availability: |
https://lilloa.univ-lille.fr/handle/20.500.12210/130444; https://hdl.handle.net/20.500.12210/130444 |
| Rights: |
Attribution-NonCommercial-NoDerivs 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.87FCF976 |
| Database: |
BASE |