| Title: |
Extending the duration of endocrine treatment for early breast cancer: patient-level meta-analysis of 12 randomised trials of aromatase inhibitors in 22 031 postmenopausal women already treated with at least 5 years of endocrine therapy |
| Authors: |
Early Breast Cancer Trialists’ Collaborative Group, EBCTCG- |
| Contributors: |
University of Oxford; Funding: Cancer Research UK and Breast Cancer Research Foundation. |
| Source: |
ISSN: 0140-6736. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2025 |
| Collection: |
Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| Subject Terms: |
[SDV.CAN]Life Sciences [q-bio]/Cancer; [SHS.STAT]Humanities and Social Sciences/Methods and statistics; [STAT]Statistics [stat]; [STAT.OT]Statistics [stat]/Other Statistics [stat.ML]; [STAT.ME]Statistics [stat]/Methodology [stat.ME] |
| Description: |
International audience ; Background In postmenopausal women with oestrogen receptor-positive early breast cancer, 5 years of adjuvant tamoxifen substantially reduces 15-year recurrence and mortality; aromatase inhibitor treatment (AIT) is even more effective. We assess the effects of further AIT among women recurrence-free after at least 5 years of endocrine therapy. Methods We conducted individual patient data meta-analyses of 12 randomised trials, including 22 031 women who had completed at least 5 years of tamoxifen, AIT, or tamoxifen then AIT, comparing subsequent AIT versus no further adjuvant therapy. Primary outcomes were recurrence of invasive breast cancer (local, distant, or new contralateral), breast cancer mortality, mortality from other causes, and all-cause mortality. Intention-to-treat analyses (irrespective of allocation adherence and stratified by age, nodal status, and trial, and censored at death from unrelated causes) yielded event rate ratios (RRs). Findings Allocation to AIT versus no further treatment reduced recurrence rates by 27% (RR 0•73 [95% CI 0•67-0•80], p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40783288; PUBMED: 40783288 |
| DOI: |
10.1016/S0140-6736(25)01013-X |
| Availability: |
https://inserm.hal.science/inserm-05224587; https://inserm.hal.science/inserm-05224587v1/document; https://inserm.hal.science/inserm-05224587v1/file/2025_Hill_Lancet.pdf; https://doi.org/10.1016/S0140-6736(25)01013-X |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.884669BF |
| Database: |
BASE |