| Title: |
The impact of age, sex, cardio-respiratory fitness and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity |
| Authors: |
Maxwell, J; Bannell, D; Brislane, A; Carter, S; Miller, GD; Roberts, KA; Hopkins, ND; Low, DA; Carter, H; Thompson, A; Claassen, J; Thijssen, D; Jones, H |
| Publisher Information: |
Springer |
| Publication Year: |
2022 |
| Collection: |
Liverpool John Moores University: LJMU Research Online |
| Subject Terms: |
QP Physiology; RC1200 Sports Medicine |
| Description: |
Background: Humans display an age-related decline in cerebral blood flow and increase in blood pressure (BP) but changes in the underlying control mechanisms across the lifespan is less well understood. We aimed to; (i) examine the impact of age, sex, cardiovascular disease (CVD) risk and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity, and (ii) explore the relationships between dynamic cerebral autoregulation and cardiac baroreflex sensitivity. Methods: 206 participants aged 18-70 years were stratified into age categories. Cerebral blood flow velocity was measured using transcranial Doppler ultrasound, repeated squat stand manoeuvres were performed (0.10 Hz) and transfer function analysis was used to assess dynamic cerebral autoregulation and cardiac baroreflex sensitivity. Multivariable linear regression was used to examine the influence of age, sex, CVD risk and cardio-respiratory fitness on dynamic cerebral autoregulation and cardiac baroreflex sensitivity. Linear models determined the relationship between dynamic cerebral autoregulation and baroreflex sensitivity. Results: Age, sex, CVD risk and cardio-respiratory fitness did not impact dynamic cerebral autoregulation normalised gain, phase or coherence with minimal change in all models (P>0.05). Baroreflex sensitivity gain was attenuated with age when adjusted for sex and CVD risk (young-older; β=-2.86 P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1439-6319 |
| Relation: |
https://researchonline.ljmu.ac.uk/id/eprint/16519/1/The%20impact%20of%20age%20sex%20cardiorespiratory%20ftness%20and%20cardiovascular%20disease%20risk%20on%20dynamic%20cerebral%20autoregulation%20and%20baroreflex%20sensitivity.pdf; Maxwell, J, Bannell, D, Brislane, A, Carter, S, Miller, GD, Roberts, KA, Hopkins, ND, Low, DA, Carter, H, Thompson, A, Claassen, J, Thijssen, D and Jones, H (2022) The impact of age, sex, cardio-respiratory fitness and cardiovascular disease risk on dynamic cerebral autoregulation and baroreflex sensitivity. European Journal of Applied Physiology. ISSN 1439-6319 |
| DOI: |
10.1007/s00421-022-04933-3 |
| Availability: |
https://researchonline.ljmu.ac.uk/id/eprint/16519/; https://researchonline.ljmu.ac.uk/id/eprint/16519/1/The%20impact%20of%20age%20sex%20cardiorespiratory%20ftness%20and%20cardiovascular%20disease%20risk%20on%20dynamic%20cerebral%20autoregulation%20and%20baroreflex%20sensitivity.pdf; https://doi.org/10.1007/s00421-022-04933-3 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.88BD7D |
| Database: |
BASE |