| Title: |
Variations in hemoglobin measurement and eligibility criteria across blood donation services are associated with differing low-hemoglobin deferral rates : a BEST collaborative study |
| Authors: |
Zalpuri, S; Romeijn, B; Allara, E; Goldman, M; Kamel, H; Gorlin, J; Vassallo, R; Grégoire, Y; Goto, N; Flanagan, P; Speedy, J; Buser, A; Kutner, JM; Magnussen, K; Castrén, J; Culler, L; Sussmann, H; Prinsze, FJ; Belanger, K; Compernolle, Veerle; Tiberghien, P; Cardenas, JM; Gandhi, MJ; West, KA; Lee, CK; James, S; Wells, D; Sutor, LJ; Wendel, S; Coleman, M; Seltsam, A; Roden, K; Steele, WR; Bohonek, M; Alcantara, R; Di Angelantonio, E; van den Hurk, K; BEST Collaborative Study, Group |
| Source: |
TRANSFUSION ; ISSN: 0041-1132 ; ISSN: 1537-2995 |
| Publication Year: |
2020 |
| Collection: |
Ghent University Academic Bibliography |
| Subject Terms: |
Medicine and Health Sciences; Biology and Life Sciences |
| Description: |
BACKGROUND Determination of blood donor hemoglobin (Hb) levels is a pre-requisite to ensure donor safety and blood product quality. We aimed to identify Hb measurement practices across blood donation services and to what extent differences associate with low-Hb deferral rates. METHODS An online survey was performed among Biomedical Excellence for Safer Transfusion (BEST) Collaborative members, extended with published data. Multivariable negative-binomial regression models were built to estimate adjusted associations of minimum donation intervals, Hb cut-offs (high, >= 13.5 g/dL in men or >= 12.5 g/dL in women, vs. lower values), iron monitoring (yes/no), providing or prescribing iron supplementation (yes/no), post-versus pre-donation Hb measurement and geographical location (Asian vs. rest), with low-Hb deferral rates. RESULTS Data were included from 38 blood services. Low-Hb deferral rates varied from 0.11% to 8.81% among men and 0.84% to 31.85% among women. Services with longer minimum donation intervals had significantly lower deferral rates among both women (rate ratio, RR 0.53, 95%CI 0.33-0.84) and men (RR 0.53, 95%CI 0.31-0.90). In women, iron supplementation was associated with lower Hb deferral rates (RR 0.47, 95%CI 0.23-0.94). Finally, being located in Asia was associated with higher low-Hb deferral rates; RR 9.10 (95%CI 3.89-21.27) for women and 6.76 (95%CI 2.45-18.68) for men. CONCLUSION Differences in Hb measurement and eligibility criteria, particularly longer donation intervals and iron supplementation in women, are associated with variations in low-Hb deferral rates. These insights could help improve both blood donation service efficiency and donor care. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://biblio.ugent.be/publication/01GWP9VB3MKWD8E5RV1SNDB1Q9; https://doi.org/10.1111/trf.15676 |
| DOI: |
10.1111/trf.15676 |
| Availability: |
https://biblio.ugent.be/publication/01GWP9VB3MKWD8E5RV1SNDB1Q9; https://hdl.handle.net/1854/LU-01GWP9VB3MKWD8E5RV1SNDB1Q9; https://doi.org/10.1111/trf.15676 |
| Accession Number: |
edsbas.88DB5E1D |
| Database: |
BASE |