Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate
| Title: | Characterization of a cisplatin-resistant human ovarian carcinoma cell line expressing cross-resistance to 5-fluorouracil but collateral sensitivity to methotrexate |
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| Authors: | Bridget T. Hill; Sharon A. Shellard; Louise K. Hosking; Cancer Res; Contact The Aacr Publications; Wolfram C. M. Dempke; Anne Marie; J. Fichtinger; Takeshi Tone; Kevin J. Scanlon; Richard D. H. Whelan |
| Contributors: | The Pennsylvania State University CiteSeerX Archives |
| Source: | http://cancerres.aacrjournals.org/content/52/11/3110.full.pdf. |
| Publication Year: | 1992 |
| Collection: | CiteSeerX |
| Description: | In vitro exposure of the TR170 ovarian carcinoma cell line to six intermittent 24-h treatments with a 90 % inhibitory concentration of cisplatin (CDDP) (0.15 «ig/ml; 0.5 /IM)resulted in a 2-fold stably resistant subline designated TRI70/CP+ (B. T. Hill et al. Int. J. Cancer, 39:219-225, 1987). Resistance to CDDP in these CP+ cells has now been associated with reduced uptake of "Sl"CDDP (2-fold; P < 0.01) and decreased removal of specific Pt-DNA adducts, quantitated immunochemically, indicative of an apparent increased tolerance of (1)1)1'induced DNA damage. Specifically these resistant cells appeared defi |
| Document Type: | text |
| File Description: | application/pdf |
| Language: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.7260; http://cancerres.aacrjournals.org/content/52/11/3110.full.pdf |
| Availability: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.335.7260; http://cancerres.aacrjournals.org/content/52/11/3110.full.pdf |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| Accession Number: | edsbas.88E72F7A |
| Database: | BASE |