| Title: |
Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study : a multicentre, prospective cohort study |
| Authors: |
Russell, CD; Fairfield, CJ; Drake, TM; Turtle, L; Seaton, RA; Wootton, DG; Sigfrid, L; Harrison, EM; Docherty, AB; de Silva, TI; Egan, C; Pius, R; Hardwick, HE; Merson, L; Girvan, M; Dunning, J; Nguyen-Van-Tam, JS; Openshaw, PJM; Baillie, JK; Semple, MG; Ho, A; Carson, G; Alex, B; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Cooke, GS; da Silva Filipe, A; Fletcher, T; Green, CA; Hiscox, JA; Ho, AYW; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lim, WS; Mentzer, AJ; Meynert, AM; Noursadeghi, M; Moore, SC; Palmarini, M; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Sancho-Shimizu, V; Scott, JT; de Silva, T; Solomon, T; Sriskandan, S; Stuart, D; Summers, C; Tedder, RS; Thomson, EC; Thompson, AAR; Thwaites, RS; Turtle, LCW; Gupta, RK; Palmieri, C; Zambon, M; Hardwick, H; Donohue, C; Lyons, R; Griffiths, F; Oosthuyzen, W; Norman, L; Knight, SR; Mclean, KA; Murphy, D; Shaw, CA; Dalton, J; Saviciute, E; Roberts, S; Harrison, J; Marsh, L; Connor, M; Halpin, S; Jackson, C; Gamble, C; Leeming, G; Wham, M; Clohisey, S; Hendry, R; Scott-Brown, J; Greenhalf, W; Shaw, V; McDonald, SE; Keating, S; Ahmed, KA; Armstrong, JA; Ashworth, M; Asiimwe, IG; Bakshi, S; Barlow, SL; Booth, L; Brennan, B; Bullock, K; Catterall, BWA; Clark, JJ; Clarke, EA; Cole, S; Cooper, L; Cox, H; Davis, C; Dincarslan, O; Dunn, C; Dyer, P; Elliott, A; Evans, A; Finch, L; Fisher, LWS; Foster, T; Garcia-Dorival, I; Gunning, P; Hartley, C; Jensen, RL; Jones, CB; Jones, TR; Khandaker, S; King, K; Kiy, RT; Koukorava, C; Lake, A; Lant, S; Latawiec, D; Lavelle-Langham, L; Lefteri, D; Lett, L; Livoti, LA; Mancini, M; McDonald, S; McEvoy, L; McLauchlan, J; Metelmann, S; Miah, NS; Middleton, J; Mitchell, J; Moore, E; Murphy, EG; Penrice-Randal, R; Pilgrim, J; Prince, T; Reynolds, W; Ridley, PM; Sales, D; Shaw, VE; Shears, RK; Small, B; Subramaniam, KS; Szemiel, A; Taggart, A; Tanianis-Hughes, J; Thomas, J; Trochu, E; van Tonder, L; Wilcock, E; Zhang, JE; Flaherty, L; Maziere, N; Cass, E; Carracedo, AD; Carlucci, N; Holmes, A; Massey, H; Murphy, L; Wrobel, N; McCafferty, S; Morrice, K; MacLean, A; Adeniji, K; Agranoff, D; Agwuh, K; Ail, D; Aldera, EL; Alegria, A; Angus, B; Ashish, A; Atkinson, D; Bari, S; Barlow, G; Barnass, S; Barrett, N; Bassford, C; Basude, S; Baxter, D; Beadsworth, M; Bernatoniene, J; Berridge, J; Best, N; Bothma, P; Chadwick, D; Brittain-Long, R; Bulteel, N; Burden, T; Burtenshaw, A; Caruth, V; Chambler, D; Chee, N; Child, J; Chukkambotla, S; Clark, T; Collini, P; Cosgrove, C; Cupitt, J; Cutino-Moguel, M-T; Dark, P; Dawson, C; Dervisevic, S; Donnison, P; Douthwaite, S; DuRand, I; Dushianthan, A; Dyer, T; Evans, C; Eziefula, C; Fegan, C; Finn, A; Fullerton, D; Garg, S; Garg, A; Gkrania-Klotsas, E; Godden, J; Goldsmith, A; Graham, C; Hardy, E; Hartshorn, S; Harvey, D; Havalda, P; Hawcutt, DB; Hobrok, M; Hodgson, L; Hormis, A; Jacobs, M; Jain, S; Jennings, P; Kaliappan, A; Kasipandian, V; Kegg, S; Kelsey, M; Kendall, J; Kerrison, C; Kerslake, I; Koch, O; Koduri, G; Koshy, G; Laha, S; Laird, S; Larkin, S; Leiner, T; Lillie, P; Limb, J; Linnett, V; Little, J; Lyttle, M; MacMahon, M; MacNaughton, E; Mankregod, R; Masson, H; Matovu, E; McCullough, K; McEwen, R; Meda, M; Mills, G; Minton, J; Mirfenderesky, M; Mohandas, K; Mok, Q; Moon, J; Morgan, P; Morris, C; Mortimore, K; Moses, S; Mpenge, M; Mulla, R; Murphy, M; Nagel, M; Nagarajan, T; Nelson, M; O'Shea, MK; Otahal, I; Ostermann, M; Pais, M; Panchatsharam, S; Papakonstantino, D; Paraiso, H; Patel, B; Pattison, N; Pepperell, J; Peters, M; Phull, M; Pintus, S; Pooni, JS; Post, F; Price, D; Prout, R; Rae, N; Reschreiter, H; Reynolds, T; Richardson, N; Roberts, M; Roberts, D; Rose, A; Rousseau, G; Ryan, B; Saluja, T; Shah, A; Shanmuga, P; Sharma, A; Shawcross, A; Sizer, J; Shankar-Hari, M; Smith, R; Snelson, C; Spittle, N; Staines, N; Stambach, T; Stewart, R; Subudhi, P; Szakmany, T; Tatham, K; Thompson, C; Thompson, R; Tridente, A; Tupper-Carey, D; Twagira, M; Ustianowski, A; Vallotton, N; Vincent-Smith, L; Visuvanathan, S; Vuylsteke, A; Waddy, S; Wake, R; Walden, A; Welters, I; Whitehouse, T; Whittaker, P; Whittington, A; Papineni, P; Wijesinghe, M; Williams, M; Wilson, L; Sarah, S; Winchester, S; Wiselka, M; Wolverson, A; Workman, A; Yates, B; Young, P |
| Publisher Information: |
Elsevier |
| Publication Year: |
2021 |
| Collection: |
White Rose Research Online (Universities of Leeds, Sheffield & York) |
| Description: |
Background Microbiological characterisation of co-infections and secondary infections in patients with COVID-19 is lacking, and antimicrobial use is high. We aimed to describe microbiologically confirmed co-infections and secondary infections, and antimicrobial use, in patients admitted to hospital with COVID-19. Methods The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) WHO Clinical Characterisation Protocol UK (CCP-UK) study is an ongoing, prospective cohort study recruiting inpatients from 260 hospitals in England, Scotland, and Wales, conducted by the ISARIC Coronavirus Clinical Characterisation Consortium. Patients with a confirmed or clinician-defined high likelihood of SARS-CoV-2 infection were eligible for inclusion in the ISARIC WHO CCP-UK study. For this specific study, we excluded patients with a recorded negative SARS-CoV-2 test result and those without a recorded outcome at 28 days after admission. Demographic, clinical, laboratory, therapeutic, and outcome data were collected using a prespecified case report form. Organisms considered clinically insignificant were excluded. Findings We analysed data from 48 902 patients admitted to hospital between Feb 6 and June 8, 2020. The median patient age was 74 years (IQR 59–84) and 20 786 (42·6%) of 48 765 patients were female. Microbiological investigations were recorded for 8649 (17·7%) of 48 902 patients, with clinically significant COVID-19-related respiratory or bloodstream culture results recorded for 1107 patients. 762 (70·6%) of 1080 infections were secondary, occurring more than 2 days after hospital admission. Staphylococcus aureus and Haemophilus influenzae were the most common pathogens causing respiratory co-infections (diagnosed ≤2 days after admission), with Enterobacteriaceae and S aureus most common in secondary respiratory infections. Bloodstream infections were most frequently caused by Escherichia coli and S aureus. Among patients with available data, 13 390 (37·0%) of 36 145 had received ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.whiterose.ac.uk/id/eprint/175330/1/1-s2.0-S2666524721000902-main.pdf; Russell, CD, Fairfield, CJ, Drake, TM et al. (369 more authors) (2021) Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study : a multicentre, prospective cohort study. The Lancet Microbe, 2 (8). e354-e365. |
| Availability: |
https://eprints.whiterose.ac.uk/id/eprint/175330/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.88F75354 |
| Database: |
BASE |