| Title: |
Computerized cognitive rehabilitation for treatment of cognitive impairment in multiple sclerosis: An explorative study |
| Authors: |
Vilou I.; Bakirtzis C.; Artemiadis A.; Ioannidis P.; Papadimitriou M.; Konstantinopoulou E.; Aretouli E.; Messinis L.; Nasios G.; Dardiotis E.; Kosmidis M.H.; Grigoriadis N. |
| Source: |
Journal of Integrative Neuroscience ; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088511694&doi=10.31083%2fj.jin.2020.02.35&partnerID=40&md5=7d8106c83abaf114555de4d6f25161e1 |
| Publication Year: |
2020 |
| Collection: |
University of Thessaly Institutional Repository / Ιδρυματικό Αποθετήριο Πανεπιστημίου Θεσσαλίας |
| Subject Terms: |
adult; Article; attention; Beck Depression Inventory; clinical article; cognitive defect; cognitive rehabilitation; cognitive reserve; controlled study; episodic memory; female; human; male; memory; mood; multiple sclerosis; processing speed; questionnaire; reading; selective attention; Stroop test; trail making test; verbal memory; visual attention; cognitive remediation therapy; complication; computer assisted therapy; middle aged; pathophysiology; physiology |
| Description: |
In this explorative study, forty-seven patients with relapsing-remitting multiple sclerosis were randomized to a custom 6-week cognitive rehabilitation intervention (n = 23) using the BrainHQTM web-based platform and to a control group condition (n = 24). Cognitive rehabilitation intervention consisted of two 40-minute sessions per week. All patients were tested with the Brief International Cognitive Assessment for Multiple Sclerosis battery, the Stroop Color-Word Test, and the trail making test, while the Beck Depression Inventory-Fast Screen questionnaire was used as a measure of mood and the cognitive reserve index as a measure of cognitive reserve. We used the reliable change index, to calculate clinically meaningful changes of performance, and to discriminate between responders and non-responders of this intervention. Statistically significant improvement of the group receiving treatment was observed mainly on measures of verbal and nonverbal episodic memory and, to a lesser extent, on reading speed, selective attention/response inhibition, and visual attention. Verbal memory and visual attention improvements remained significant after considering the corrected for multiple comparisons level of significance. According to reliable change index scores, 12/23 (52.2%) of patients in the intervention group presented meaningful improvement in at least one measure (Greek Verbal Learning Test: 26%, Brief Visuospatial Memory Test-Revised: 17.4%, Stroop-Words test: 13%). This explorative study provides evidence that, at least in the short term, cognitive rehabilitation may improve the cognitive performance of multiple sclerosis patients. © 2020 IMR Press Limited. All rights reserved. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
02196352 |
| Relation: |
https://hdl.handle.net/11615/80628 |
| DOI: |
10.31083/j.jin.2020.02.35 |
| Availability: |
https://hdl.handle.net/11615/80628; https://doi.org/10.31083/j.jin.2020.02.35 |
| Accession Number: |
edsbas.8908A394 |
| Database: |
BASE |