| Title: |
Synergistic control of neurotransmitter release by different members of the synaptotagmin family |
| Authors: |
Volynski, KE; Krishnakumar, SS |
| Source: |
Current Opinion in Neurobiology , 51 pp. 154-162. (2018) |
| Publication Year: |
2018 |
| Collection: |
University College London: UCL Discovery |
| Description: |
Quantal neurotransmitter release at nerve terminals is tightly regulated by the presynaptic Ca2+ concentration. Here, we summarise current advances in understanding how the interplay between presynaptic Ca2+ dynamics and different Ca2+ release sensors shapes action potential-evoked release on a timescale from hundreds of microseconds to hundreds of milliseconds. In particular, we review recent studies that reveal the synergistic roles of the low Ca2+ affinity/fast release sensors synaptotagmins 1, 2 and 9 and the high affinity/slow release sensor synaptotagmin 7 in the regulation of synchronous and asynchronous release and of short-term synaptic plasticity. We also examine new biochemical and structural data and outline a working model that could potentially explain the cooperative roles of different synaptotagmins in molecular terms. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10052433/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10052433/1/2018-Volynski-Krishnakumar-Review_Accepted.pdf; https://discovery.ucl.ac.uk/id/eprint/10052433/ |
| Rights: |
open |
| Accession Number: |
edsbas.89195AF5 |
| Database: |
BASE |