| Title: |
MCR XVII. Three Types of MCRs and the Libraries – Their Chemistry of Natural Events and Preparative Chemistry |
| Authors: |
Ugi, Ivar; Almstetter, Michael; Bock, Holger; Dömling, Alexander; Ebert, Birgit; Gruber, Bernhard; Hanusch-Kompa, Cordelia; Heck, Stefan; Kehagia-Drikos, Konstantina; Lorenz, Klaus; Papathoma, Sofia; Raditschnig, Robert; Schmid, Thomas; Werner, Birgit; von Zychlinski, Alexander |
| Source: |
Croatica Chemica Acta ; ISSN 1334-417X (Online) ; ISSN 0011-1643 (Print) ; ISSN-L 0011-1643 ; CODEN CCACAA ; Volume 71 ; Issue 3 |
| Publisher Information: |
Croatian Chemical Society |
| Publication Year: |
1998 |
| Collection: |
Hrčak - Portal of scientific journals of Croatia / Portal znanstvenih časopisa Republike Hrvatske |
| Description: |
The one-pot Multicomponent Reactions (MCRs)1 convert more than two different components into their products with at least two new chemical bonds, and the products contain all educts or at least some parts of them. Many chemical reactions have several, but not all, aspects of the MCRs. Three different basic types (I–III) and two subclasses (A and B) of MCRs can take place. Chemistry had started in the nature of our world roughly 4.6 billion years ago, including MCRs of the types I and II, forming libraries of many different products. A little later, the living cells came into existence, and their biochemical MCRs of all three types started. In their various local parts their biochemical products are selectively formed by their enzyme-assisted procedures, but many of their MCRs belong to type III. The preparative chemistry of MCRs started in the middle of the last century, when the first equilibrating but isolateable 3CR products of type IB were formed. The pre-final reactions of type I form compounds, which react further and form their final products irreversibly by MCRs of type II. The type IIA products are usually heterocycles, whereas those of type IIB are generally products of isocyanides. The U-4CR of type IIB was introduced and this led to a new preparative MCR chemistry. Their educts and intermediate products equilibrate (type IA) and undergo irreversible CII → CIV &alpha,-additions of the isocyanides, followed by a variety of rearrangements into their final products (type IIB). In recent years, unions of higher numbers of components were introduced, forming even more diverse types of products. The MCR libraries were proposed in 1961, and since 1995 this chemistry has become an essential part of the chemical research in industrial search for new desirable products. This methodology requires much less work than all previous methods and proceeds many orders of magnitude faster. |
| Document Type: |
conference object |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://hrcak.srce.hr/132365 |
| Availability: |
https://hrcak.srce.hr/132365; https://hrcak.srce.hr/file/195381 |
| Rights: |
info:eu-repo/semantics/openAccess ; Croatica Chemica Acta is at the highest possible level of Open Access, meaning that all content is immediately and freely available to anyone, anywhere, to be downloaded, printed, distributed, read, reused, self archived, and re-mixed (including commercially) without restriction, as long as the author and the original source are properly at-tributed according to the Creative Commons Attribution 4.0 International License (CC BY). The author(s) hold the copyright and retain publishing rights without restrictions. CC BY (Creative Commons Attribution) is the most accommodating of public copyright licenses as defined by Creative Commons, a nonprofit organization that provides legal tools for sharing and use of creative works and research. The CC BY license is recommended for maximum dissemination and use of licensed materials. All content published in Croatica Chemica Acta is available under CC BY, meaning anyone is free to use and reuse the content provided the original source and authors are credited. The copyright is held and retained. The author(s) hold the copyright without restrictions. CC BY is the appropriate license for publicly funded research; it maximizes the potential for both economic and scholarly impact, protects the rights of authors and strengthens the long-standing tradition of appropriate attribution and credit for scholarship. |
| Accession Number: |
edsbas.89205668 |
| Database: |
BASE |