| Title: |
A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine |
| Authors: |
Guo, Y. (Yanjun); Rist, P.M. (Pamela M.); Daghlas, I. (Iyas); Giulianini, F. (Franco); Gormley, A.M.; Anttila, V. (Verneri); Winsvold, B.S. (Bendik S.); Palta, P. (Priit); Esko, T. (Tonu); Pers, T.H. (Tune H.); Farh, K.-H. (Kai-How); Cuenca-Leon, E. (Ester); Muona, M. (Mikko); Furlotte, N.A. (Nicholas A.); Kurth, T. (Tobias); Ingason, A. (Andres); McMahon, G. (George); Ligthart, L. (Lannie); Terwindt, G.M. (Gisela); Todt, U. (Unda); Müller-Myhsok, B. (Bertram); Ran, C. (Caroline); Gordon, S.D. (Scott D.); Stam, A.H. (Anine); Steinberg, S. (Stacy); Borck, G. (Guntram); Koiranen, M. (Markku); Quaye, L. (Lydia); Adams, H.H.H. (Hieab H. H.); Lehtimäki, T. (Terho); Sarin, A.-P.; Wedenoja, J. (Juho); Hinds, D.A. (David A.); Buring, J.E. (Julie E.); Schürks, M. (Markus); Ridker, P.M. (Paul M.); Hrafnsdottir, M.G. (Maria Gudlaug); Stefansson, H. (Hreinn); Ring, S.M. (Susan M.); Hottenga, J.J. (Jouke Jan); Penninx, B.W.J.H. (Brenda W. J. H.); Färkkilä, M. (Markus); Artto, V. (Ville); Kaunisto, M.A. (Mari); Vepsäläinen, S. (Salli); Malik, R. (Rainer); Heath, A.C. (Andrew C.); Madden, P.A. (Pamela); Martin, N.G. (Nicholas); Montgomery, G.W. (Grant); Kurki, M. (Mitja); Kals, M. (Mart); Mägi, R. (Reedik); Pärn, K. (Kalle); Hämäläinen, E. (Eija); Huang, H. (Hailiang); Byrnes, A.E. (Andrea E.); Franke, L. (Lude); Huang, J. (Jie); Stergiakouli, E. (Evie); Lee, P.H. (Phil H.); Sandor, C. (Cynthia); Webber, C. (Caleb); Cader, Z. (Zameel); Müller-Myhsok, B. (B.); Schreiber, S. (Stefan); Meitinger, T. (Thomas); Hagen, K. (Knut); Salomaa, V. (Veikko); Heikkilä, K. (Kauko); Loehrer, E. (Elizabeth); Uitterlinden, A.G. (André); Hofman, A. (Albert); Duijn, C.M. (Cornelia) van; Cherkas, L. (Lynn); Pedersen, L.M. (Linda M.); Stubhaug, A. (Audun); Nielsen, C.S. (Christopher S.); Männikkö, M. (Minna); Mihailov, E. (Evelin); Milani, L. (Lili); Esserlind, A.-L. (Ann-Louise); Christensen, A.F. (Anne Francke); Hansen, T. (Thomas); Werge, T.M. (Thomas); Kaprio, J. (Jaakko); Aromaa, A. (Arpo); Raitakari, O. (Olli); Ikram, M.A. (Arfan); Spector, T.D. (Timothy); Järvelin, M.-R. (Marjo-Riitta); Metspalu, A. (Andres); Kubisch, C. (Christian); Beckmann, J.S. (Jacques); Ferrari, M.D. (Michel); Belin, A.C. (Andrea C.); Wessman, M. (Maija); Maagdenberg, A.M.J.M. (Arn M. J. M. van den); Zwart, J-A. (John-Anker); Boomsma, D.I. (Dorret); Smith, G.D. (George Davey); Stefansson, K. (Kari); Eriksson, N. (Nicholas); Daly, M.J. (Mark J.); Neale, B.M. (Benjamin); Olesen, J. (Jes); Chasman, D.I. (Daniel I.); Nyholt, D.R. (Dale R.); Palotie, A. (Aarno); Agee, M. (Michelle); Auton, A. (Adam); Bell, R.K. (Robert K.); Bryc, K. (Katarzyna); Elson, S.L. (Sarah L.); Fontanillas, P. (Pierre); Huber, K.E. (Karen E.); Kleinman, A. (Aaron); Litterman, N.K. (Nadia K.); McCreight, J.C. (Jennifer C.); McIntyre, M.H. (Matthew H.); Mountain, J.L. (Joanna L.); Noblin, E.S. (Elizabeth S.); Northover, C.A.M. (Carrie A. M.); Pitts, S.J. (Steven J.); Sathirapongsasuti, J.F. (J. Fah); Sazonova, O.V. (Olga V.); Shelton, J.F. (Janie F.); Shringarpure, S. (Suyash); Tian, C. (Chao); Tung, J.Y. (Joyce Y.); Vacic, V. (Vladimir); Kurth, K.H. (Karl); Chasman, D.I. (Daniel) |
| Source: |
Nature Communications vol. 11 no. 1 |
| Publication Year: |
2020 |
| Collection: |
RePub - Publications from Erasmus University, Rotterdam |
| Description: |
Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in migraine prophylaxis are unknown. Leveraging large-scale summary statistics for migraine (Ncases/Ncontrols = 59,674/316,078) and BP (N = 757,601), we find positive genetic correlations of migraine with diastolic BP (DBP, rg = 0.11, P = 3.56 × 10−06) and systolic BP (SBP, rg = 0.06, P = 0.01), but not pulse pressure (PP, rg = −0.01, P = 0.75). Cross-trait meta-analysis reveals 14 shared loci (P ≤ 5 × 10−08), nine of which replicate (P < 0.05) in the UK Biobank. Five shared loci (ITGB5, SMG6, ADRA2B, ANKDD1B, and KIAA0040) are reinforced in gene-level analysis and highlight potential mechanisms involving vascular development, endothelial function and calcium homeostasis. Mendelian randomization reveals stronger instrumental estimates of DBP (OR [95% CI] = 1.20 [1.15–1.25]/10 mmHg; P = 5.57 × 10−25) on migraine than SBP (1.05 [1.03–1.07]/10 mmHg; P = 2.60 × 10−07) and a corresponding opposite effect for PP (0.92 [0.88–0.95]/10 mmHg; P = 3.65 × 10−07). These findings support a critical role of DBP in migraine susceptibility and shared biology underlying BP and migraine. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://repub.eur.nl/pub/128648; urn:hdl:1765/128648 |
| DOI: |
10.1038/s41467-020-17002-0 |
| Availability: |
https://repub.eur.nl/pub/128648; https://doi.org/10.1038/s41467-020-17002-0 |
| Accession Number: |
edsbas.8925E10E |
| Database: |
BASE |