| Title: |
A novel nuclear receptor/coregulator complex controls C. elegans lipid metabolism, larval development, and aging |
| Authors: |
Ludewig, Andreas H.; Kober-Eisermann, Corinna; Weitzel, Cindy; Bethke, Axel; Neubert, Kerstin; Gerisch, Birgit; Hutter, Harald; Antebi, Adam |
| Publisher Information: |
Cold Spring Harbor Laboratory Press |
| Publication Year: |
2004 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Research Papers |
| Description: |
Environmental cues transduced by an endocrine network converge on Caenorhabditis elegans nuclear receptor DAF-12 to mediate arrest at dauer diapause or continuous larval development. In adults, DAF-12 selects long-lived or short-lived modes. How these organismal choices are molecularly specified is unknown. Here we show that coregulator DIN-1 and DAF-12 physically and genetically interact to instruct organismal fates. Homologous to human corepressor SHARP, DIN-1 comes in long (L) and short (S) isoforms, which are nuclear localized but have distinct functions. DIN-1L has embryonic and larval developmental roles. DIN-1S, along with DAF-12, regulates lipid metabolism, larval stage-specific programs, diapause, and longevity. Epistasis experiments reveal that din-1S acts in the dauer pathways downstream of lipophilic hormone, insulin/IGF, and TGFβ signaling, the same point as daf-12 . We propose that the DIN-1S/DAF-12 complex serves as a molecular switch that implements slow life history alternatives in response to diminished hormonal signals. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://www.genesdev.org/cgi/content/short/18/17/2120; http://dx.doi.org/10.1101/gad.312604 |
| DOI: |
10.1101/gad.312604 |
| Availability: |
http://www.genesdev.org/cgi/content/short/18/17/2120; https://doi.org/10.1101/gad.312604 |
| Rights: |
Copyright (C) 2004, Cold Spring Harbor Laboratory Press |
| Accession Number: |
edsbas.896E08DA |
| Database: |
BASE |