| Title: |
Early-Life Exposure to Air Pollution and Childhood Asthma Cumulative Incidence in the ECHO CREW Consortium |
| Authors: |
Zanobetti, Antonella; Ryan, Patrick H.; Coull, Brent A.; Luttmann-Gibson, Heike; Datta, Soma; Blossom, Jeffrey; Brokamp, Cole; Lothrop, Nathan; Miller, Rachel L.; Beamer, Paloma I.; Visness, Cynthia M.; Andrews, Howard; Bacharier, Leonard B.; Hartert, Tina; Johnson, Christine C.; Ownby, Dennis R.; Khurana Hershey, Gurjit K.; Joseph, Christine L.M.; Mendonça, Eneida A.; Jackson, Daniel J.; Zoratti, Edward M.; Wright, Anne L.; Martinez, Fernando D.; Seroogy, Christine M.; Ramratnam, Sima K.; Calatroni, Agustin; Gern, James E.; Gold, Diane R. |
| Source: |
JAMA Network Open ; volume 7, issue 2, page e240535 ; ISSN 2574-3805 |
| Publisher Information: |
American Medical Association (AMA) |
| Publication Year: |
2024 |
| Description: |
Importance Exposure to outdoor air pollution contributes to childhood asthma development, but many studies lack the geographic, racial and ethnic, and socioeconomic diversity to evaluate susceptibility by individual-level and community-level contextual factors. Objective To examine early life exposure to fine particulate matter (PM 2.5 ) and nitrogen oxide (NO 2 ) air pollution and asthma risk by early and middle childhood, and whether individual and community-level characteristics modify associations between air pollution exposure and asthma. Design, Setting, and Participants This cohort study included children enrolled in cohorts participating in the Children’s Respiratory and Environmental Workgroup consortium. The birth cohorts were located throughout the US, recruited between 1987 and 2007, and followed up through age 11 years. The survival analysis was adjusted for mother’s education, parental asthma, smoking during pregnancy, child’s race and ethnicity, sex, neighborhood characteristics, and cohort. Statistical analysis was performed from February 2022 to December 2023. Exposure Early-life exposures to PM 2.5 and NO 2 according to participants’ birth address. Main Outcomes and Measures Caregiver report of physician-diagnosed asthma through early (age 4 years) and middle (age 11 years) childhood. Results Among 5279 children included, 1659 (31.4%) were Black, 835 (15.8%) were Hispanic, 2555 (48.4%) where White, and 229 (4.3%) were other race or ethnicity; 2721 (51.5%) were male and 2596 (49.2%) were female; 1305 children (24.7%) had asthma by 11 years of age and 954 (18.1%) had asthma by 4 years of age. Mean values of pollutants over the first 3 years of life were associated with asthma incidence. A 1 IQR increase in NO 2 (6.1 μg/m 3 ) was associated with increased asthma incidence among children younger than 5 years (HR, 1.25 [95% CI, 1.03-1.52]) and children younger than 11 years (HR, 1.22 [95% CI, 1.04-1.44]). A 1 IQR increase in PM 2.5 (3.4 μg/m 3 ) was associated with increased asthma incidence among ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1001/jamanetworkopen.2024.0535 |
| Availability: |
https://doi.org/10.1001/jamanetworkopen.2024.0535; https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2815586/zanobetti_2024_oi_240043_1708501353.82175.pdf |
| Accession Number: |
edsbas.89BF3186 |
| Database: |
BASE |