| Title: |
In vitro and in vivo anticryptococcal activities of a new pyrazolo-isothiazole derivative |
| Authors: |
Barchiesi, Francesco; Milici, Maria E.; Arzeni, Daniela; Schimizzi, Anna M.; Pizzo, Giuseppe; Giammanco, Giovanni; Giannini, Daniele; Manfrini, Maurizio; Scalise, Giorgio; Vicentini, Chiara B. |
| Contributors: |
Barchiesi, Francesco*; Milici, Maria E.; Arzeni, Daniela; Schimizzi, Anna M.; Pizzo, Giuseppe; Giammanco, Giovanni; Giannini, Daniele; Manfrini, Maurizio; Scalise, Giorgio; Vicentini, Chiara B. |
| Publication Year: |
2003 |
| Collection: |
IRIS Università degli Studi di Palermo |
| Subject Terms: |
Pharmacology; Pharmacology (medical); Infectious Diseases; Settore MED/07 - Microbiologia E Microbiologia Clinica |
| Description: |
We investigated the activity of a pyrazolo-isothiazole derivative (G8) against Cryptococcus neoformans. A first screening test showed that G8 at 10 mg/L inhibited the growth of 14 of 15 clinical isolates tested. Killing experiments showed that fungicidal activity was achieved after 8 h of treatment with G8 at concentrations ≥10 mg/L. In a murine model of systemic cryptococcosis, G8 was effective at prolonging survival compared with the controls. Our data indicate that this new derivative has a potential therapeutic role in infections caused by C. neoformans. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/12493804; info:eu-repo/semantics/altIdentifier/wos/WOS:000179952200026; volume:51; issue:1; firstpage:167; lastpage:170; numberofpages:4; journal:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY; https://hdl.handle.net/10447/344199 |
| DOI: |
10.1093/jac/dkg019 |
| Availability: |
https://hdl.handle.net/10447/344199; https://doi.org/10.1093/jac/dkg019 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.89F2E029 |
| Database: |
BASE |