| Title: |
Measuring calcitonin in washout of the needle in patients undergoing fine needle aspiration with suspicious medullary thyroid cancer |
| Authors: |
Trimboli, P.; Rossi, F.; Baldelli, R.; Laurenti, O.; Nigri, G.; Ventura, C.; Appetecchia, M.; Attanasio, D.; Romanelli, F.; Guidobaldi, L.; Guarino, M.; Crescenzi, A.; Valabrega, S. |
| Source: |
Diagnostic Cytopathology ; volume 40, issue 5, page 394-398 ; ISSN 8755-1039 1097-0339 |
| Publisher Information: |
Wiley |
| Publication Year: |
2011 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Calcitonin measurement in washout of the needle after aspiration (WO‐Ct) has been rarely evaluated. Here we analyzed the role of WO‐Ct in a series of subjects who underwent fine needle aspiration (FNA) with suspicious medullary thyroid cancer (MTC). Twenty‐one patients referred following elevated serum calcitonin (S‐Ct) or suspicious MTC by cytology. All patients underwent re‐evaluation of S‐Ct, FNA, and measurement of WO‐Ct. S‐Ct and WO‐Ct were assessed by chemiluminescence assay (IMMULITE 2000, Diagnostic Products Corporation, USA). S‐Ct showed elevated value in six subjects (mean 368.8 ± 373.9 pg/ml), of which three cases were cytologically classified as Class 5. WO‐Ct obtained in this group (304.0 ± 309.3 pg/ml) was no different from S‐Ct. After surgery MTC was confirmed in all patients. In the other 15 patients MTC was excluded by cytology or histology. Two subjects had moderately skewed S‐Ct with nonmedullary histology. In the remaining 13 patients S‐Ct resulted normal (6.2 ± 5.6 pg/ml) and WO‐Ct low (2.9 ± 2.2 pg/ml). Significant (two‐tailed P < 0.05, r 2 = 0.27, 95% confidence interval = 0.017–0.81) correlation was found between S‐Ct and WO‐Ct in nonmedullary patients but not in MTC patients. This study showed that WO‐Ct can play a role in diagnosing primary and metastatic MTC. The procedure is easy, cost effective, and should be used in patients undergoing FNA with elevated S‐Ct. Further studies and guidelines for the method are needed to use this technique in clinical routine. Until this any institute should use itself cut‐off. Diagn. Cytopathol. 2011. © 2011 Wiley‐Liss, Inc. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1002/dc.21731 |
| Availability: |
https://doi.org/10.1002/dc.21731; https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fdc.21731; https://onlinelibrary.wiley.com/doi/pdf/10.1002/dc.21731 |
| Rights: |
http://onlinelibrary.wiley.com/termsAndConditions#vor |
| Accession Number: |
edsbas.8A155279 |
| Database: |
BASE |