| Title: |
Inspiratory muscle reflex control after incomplete cervical spinal cord injury |
| Authors: |
McNaughton, KMD; Witherow, JL; Dupuche, CB; Peebles, KC; Elphick, TG; Hudson, AL; McCaughey, EJ; Boswell-Ruys, CL; Butler, JE |
| Source: |
urn:ISSN:8750-7587 ; urn:ISSN:1522-1601 ; Journal of Applied Physiology, 133, 6, 1318-1326 |
| Publisher Information: |
American Physiological Society |
| Publication Year: |
2022 |
| Collection: |
UNSW Sydney (The University of New South Wales): UNSWorks |
| Subject Terms: |
32 Biomedical and Clinical Sciences; 3208 Medical Physiology; 3201 Cardiovascular Medicine and Haematology; 3202 Clinical Sciences; Traumatic Head and Spine Injury; Physical Injury - Accidents and Adverse Effects; Neurodegenerative; Spinal Cord Injury; Lung; Sleep Research; Neurosciences; Neurological; Humans; Cervical Cord; Reflex; Muscles; aspiration; diaphragm; scalene; anzsrc-for: 32 Biomedical and Clinical Sciences; anzsrc-for: 3208 Medical Physiology; anzsrc-for: 3201 Cardiovascular Medicine and Haematology; anzsrc-for: 3202 Clinical Sciences; anzsrc-for: 06 Biological Sciences; anzsrc-for: 11 Medical and Health Sciences; anzsrc-for: 31 Biological sciences; anzsrc-for: 42 Health sciences |
| Description: |
In healthy individuals, loading inspiratory muscles by brief inspiratory occlusion produces a short-latency inhibitory reflex (IR) in the electromyographic (EMG) activity of scalene and diaphragm muscles. This IR may play a protective role to prevent aspiration and airway collapse during sleep. In people with motor and sensory complete cervical spinal cord injury (cSCI), who were able to breathe independently, this IR was predominantly absent. Here, we investigated the reflex response to brief airway occlusion in 16 participants with sensory incomplete cSCI [American spinal injury association impairment scale (AIS) score B or C]. Surface EMG was recorded from scalene muscles and the lateral chest wall (overlying diaphragm). The airway occlusion evoked a small change in mouth pressure resembling a physiological occlusion. The short-latency IR was present in 10 (63%) sensory incomplete cSCI participants; significantly higher than the IR incidence observed in complete cSCI participants in our previous study (14%; P = 0.003). When present, mean IR latency across all muscles was 58 ms (range 29-79 ms), and mean rectified EMG amplitude decreased to 37% preocclusion levels. Participants without an IR had untreated severe obstructive sleep apnea (OSA), in contrast to those with an IR, who had either had no, mild, or treated OSA (P = 0.002). Insufficient power did not allow statistical comparison between IR presence or absence and participant clinical characteristics. In conclusion, spared sensory connections or intersegmental connections may be necessary to generate the IR. Future studies to establish whether IR presence is related to respiratory morbidity in the tetraplegic population are required. NEW & NOTEWORTHY Individuals with incomplete cSCI were tested for the presence of a short latency reflex inhibition of inspiratory muscles, by brief airway occlusion. The reflex was 4.5 times more prevalent in this group compared with those with complete cSCI and is similar to the incidence in able-bodied people. ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://hdl.handle.net/1959.4/unsworks_82490; https://doi.org/10.1152/japplphysiol.00113.2022 |
| DOI: |
10.1152/japplphysiol.00113.2022 |
| Availability: |
https://hdl.handle.net/1959.4/unsworks_82490; https://unsworks.unsw.edu.au/bitstreams/7ef28ac0-e28d-4a08-8ed8-a64e16984497/download; https://doi.org/10.1152/japplphysiol.00113.2022 |
| Rights: |
open access ; https://purl.org/coar/access_right/c_abf2 ; CC-BY ; https://creativecommons.org/licenses/by/4.0/ ; free_to_read |
| Accession Number: |
edsbas.8A3AFFC3 |
| Database: |
BASE |