| Title: |
'Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature'. |
| Authors: |
Clarke, Sarah LN; Mageean, Katie S; Carlton, Henry; Simonini, Gabriele; Sharp, Gemma C; Relton, Caroline L; Ramanan, Athimalaipet V |
| Publisher Information: |
Springer Science and Business Media LLC |
| Publication Year: |
2021 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
BACKGROUND: Juvenile idiopathic arthritis associated uveitis (JIA-U) is the most common extra-articular manifestation of juvenile idiopathic arthritis (JIA) and carries considerable risk to vision. The aim of this systematic review was to synthesise evidence of environmental risk factors for JIA-U and identify risk factors which may be modifiable or used to stratify JIA patients. METHODS: This systematic review was carried out in accordance with PRISMA guidelines. Four online databases - Cumulative Index of Nursing and Allied Health Literature, Web of Science, MEDLINE and Embase - were searched from database inception to 12th August 2020. Identified studies were screened by two independent reviewers against pre-defined inclusion and exclusion criteria. Data was extracted from all primary studies meeting inclusion criteria and independently checked. RESULTS: We identified three studies from 895 unique records which met the inclusion criteria, each examining a different environmental risk factor. This systematic review includes 973, predominantly female, participants with JIA across these three studies. The use of allergy medication or documentation of "allergy"/"allergic" in the medical records was associated with an increased risk of JIA-U in all models presented. Vitamin D sufficiency was associated with reduced risk of JIA-U. There was insufficient evidence to support an association between seasonality and JIA-U. CONCLUSIONS: This review identifies a potential role for allergy and vitamin D in JIA-U. It also illustrates the paucity of data regarding environmental risk factors for JIA-U and highlights the need for further research to both identify additional risk factors and replicate existing findings. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1869-5760 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4669617/1/Clarke-etal-2021-environmental-risk-factors.pdf; Clarke, Sarah LNORCID logo; Mageean, Katie S; Carlton, Henry; Simonini, Gabriele; Sharp, Gemma C; Relton, Caroline L ORCID logo; and Ramanan, Athimalaipet V (2021) "Environmental risk factors associated with juvenile idiopathic arthritis associated uveitis: a systematic review of the literature". Journal of ophthalmic inflammation and infection, 11 (1). 15-. ISSN 1869-5760 DOI:10.1186/s12348-021-00247-1 |
| DOI: |
10.1186/s12348-021-00247-1 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4669617/; https://doi.org/10.1186/s12348-021-00247-1 |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.8A570DDE |
| Database: |
BASE |