Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury
| Title: | Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury |
|---|---|
| Authors: | Carr, DF; Ayehunie, S; Davies, A; Duckworth, CA; French, S; Hall, N; Hussain, S; Mellor, HR; Norris, A; Park, BK; Penrose, A; Pritchard, DM; Probert, CS; Ramaiah, S; Sadler, C; Schmitt, M; Shaw, A; Sidaway, JE; Vries, RG; Wagoner, M; Pirmohamed, M |
| Publisher Information: | Elsevier BV |
| Publication Year: | 2017 |
| Collection: | The University of Liverpool Repository |
| Description: | Adverse drug reactions affecting the gastrointestinal (GI) tract are a serious burden on patients, healthcare providers and the pharmaceutical industry. GI toxicity encompasses a range of pathologies in different parts of the GI tract. However, to date no specific mechanistic diagnostic/prognostic biomarkers or translatable pre-clinical models of GI toxicity exist. This review will cover the current knowledge of GI ADRs, existing biomarkers and models with potential application for toxicity screening/monitoring. We focus on the current gaps in our knowledge, the potential opportunities and recommend that a systematic approach is needed to identify mechanism-based GI biomarkers with potential for clinical translation. |
| Document Type: | article in journal/newspaper |
| File Description: | text |
| Language: | English |
| ISSN: | 0163-7258 |
| Relation: | https://livrepository.liverpool.ac.uk/3004887/1/Post_review_PandT%20version_MP.docx; Collapse authors list. Carr, DF, Ayehunie, S, Davies, A, Duckworth, CA orcid:0000-0001-7971-3561 , French, S, Hall, N, Hussain, S, Mellor, HR, Norris, A, Park, BK orcid:0000-0001-8384-824X et al (show 11 more authors) , Penrose, A, Pritchard, DM orcid:0000-0001-7971-3561 , Probert, CS orcid:0000-0003-0477-6714 , Ramaiah, S, Sadler, C, Schmitt, M, Shaw, A, Sidaway, JE, Vries, RG, Wagoner, M and Pirmohamed, M orcid:0000-0002-7534-7266 (2017) Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury Pharmacology and Therapeutics, 172. pp. 181-194. ISSN 0163-7258, 1879-016X |
| DOI: | 10.1016/j.pharmthera.2017.01.002 |
| Availability: | https://livrepository.liverpool.ac.uk/3004887/; https://doi.org/10.1016/j.pharmthera.2017.01.002; https://livrepository.liverpool.ac.uk/3004887/1/Post_review_PandT%20version_MP.docx |
| Accession Number: | edsbas.8A74693F |
| Database: | BASE |