| Title: |
Multigenerational effects of uranium exposure reveal stronger testicular dysregulation in the second generation |
| Authors: |
Legendre, Audrey; Gloaguen, Celine; Kereselidze, Dimitri; Saci, Nawel; El Houdigui, Sophia Murat; Froment, Pascal; Elie, Christelle; Defoort, Catherine; Lestaevel, Philippe; Benadjaoud, Mohamed‐amine; Souidi, Maamar; Grison, Stephane |
| Contributors: |
Laboratoire de radiotoxicologie et radiobiologie expérimentale (ASNR/PSE-SANTE/SESANE/LRTOX); Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (ASNR/PSE-SANTE/SESANE); Autorité de Sûreté Nucléaire et de Radioprotection (ASNR)-Autorité de Sûreté Nucléaire et de Radioprotection (ASNR); Service du partage des connaissances et de l'archivage (ASNR/USNR/SEARCH); Université de la Sûreté Nucléaire et de la Radioprotection (ASNR/USNR); Physiologie de la reproduction et des comportements Nouzilly (PRC); Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Centre recherche en CardioVasculaire et Nutrition = Center for CardioVascular and Nutrition research (C2VN); Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Laboratoire de Radiobiologie des expositions accidentelles (ASNR/PSE-SANTE/SERAMED/LRAcc); Service de recherche en radiobiologie et en médecine régénérative (ASNR/PSE-SANTE/SERAMED); Autorité de Sûreté nucléaire et de Radioprotection - ASNR (France) |
| Source: |
ISSN: 2666-027X ; Current Research in Toxicology ; https://hal.inrae.fr/hal-05496753 ; Current Research in Toxicology, 2026, 10, pp.100279. ⟨10.1016/j.crtox.2025.100279⟩. |
| Publisher Information: |
CCSD; ELSEVIER |
| Publication Year: |
2026 |
| Collection: |
Université François-Rabelais de Tours: HAL |
| Subject Terms: |
Uranium; Multigenerational exposure; Low-dose; Endocrine disruption; Testicular toxicity; [SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Background: Infertility is a significant public health issue that can be influenced by environmental pollutants. As a radioactive heavy metal and environmental contaminant, uranium has the potential to impact fertility. Objective: This study assesses the multigenerational reproductive effects of chronic, non-nephrotoxic uranium exposure across three generations of male rats.Methods: In this study, a non-nephrotoxic uranium solution (40 mg/L) was chronically administered via drinking water to male and female F0 rats (n = 20 per group) throughout their lifespan. The objective was to evaluate the potential reprotoxic effects of uranium on males across three generations (F0, F1, F2), with a focus on spermatogenesis, steroidogenesis, and testicular homeostasis, including oxidative stress, inflammation, apoptosis, and vitamin D metabolism.Results: Steroidogenesis was modulated in all generation, with dysregulation of sex and pituitary hormones (testosterone, estradiol, gonadotropins, Luteinizing Hormone (LH), Follicle-Stimulating Hormone (FSH). Morphological and histological changes in the testes were observed in both the F1 and F2 generations. Spermatogenesis was dysregulated by an increased proportion of seminiferous tubules at stage I-VI and reduced expression of TH2B and eppin mRNA. Interestingly, gene expression analysis of several markers involved in the regulation and protection of testicular homeostasis revealed significant effects only on the F2 generation. In this generation, uranium exposure also disrupted vitamin D metabolism in the testes.Conclusion: Uranium may impair testicular function, with more pronounced effects observed in the F2 generation. These findings highlight its potential for multigenerational toxicity and underscore the need for further research into its impact on human reproductive health. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
WOS: 001672643300001 |
| DOI: |
10.1016/j.crtox.2025.100279 |
| Availability: |
https://hal.inrae.fr/hal-05496753; https://hal.inrae.fr/hal-05496753v1/document; https://hal.inrae.fr/hal-05496753v1/file/Multigenerational%20effects%20of%20uranium%20exposure.pdf; https://doi.org/10.1016/j.crtox.2025.100279 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.8ABD05E8 |
| Database: |
BASE |