| Title: |
Regulatory Effects of Astragaloside IV on Hyperglycemia-Induced Mitophagy in Schwann Cells |
| Authors: |
Wei, Xiaoyi; Zheng, Yalin; Ai, Yanke; Li, Buman |
| Contributors: |
Xu, Youhua; National Natural Science Foundation of China; Beijing Municipal Commission of Education |
| Source: |
Evidence-Based Complementary and Alternative Medicine ; volume 2022, page 1-8 ; ISSN 1741-4288 1741-427X |
| Publisher Information: |
Wiley |
| Publication Year: |
2022 |
| Collection: |
Wiley Online Library (Open Access Articles via Crossref) |
| Description: |
Objective. This study aimed to observe the regulatory effects of astragaloside IV (AS-IV) on hyperglycemia-induced mitochondrial damage and mitophagy in Schwann cells and to provide references for clinical trials on AS-IV in the treatment of diabetic peripheral neuropathy. Methods. Schwann cells were grown in a high-glucose medium to construct an autophagy model; the cells were then treated with AS-IV and N-acetylcysteine (control) to observe the regulatory effects of AS-IV on oxidative stress and mitophagy. Results. AS-IV exhibited antioxidant activity and inhibited the overactivation of autophagy in Schwann cells, significantly reducing the level of reactive oxygen species and downregulating the expression of autophagy-related proteins (LC3, PINK, and Parkin) under hyperglycemic conditions, thereby exerting a protective effect on mitochondrial morphology and membrane potential. Conclusion. AS-IV can maintain the mitochondrial function of Schwann cells under hyperglycemic conditions by effectively alleviating oxidative stress and overactivation of mitophagy. The evidence from this study supports an AS-IV-based therapeutic strategy against diabetic peripheral neuropathy. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1155/2022/7864308 |
| Availability: |
https://doi.org/10.1155/2022/7864308; http://downloads.hindawi.com/journals/ecam/2022/7864308.pdf; http://downloads.hindawi.com/journals/ecam/2022/7864308.xml |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.8ACF5313 |
| Database: |
BASE |