| Title: |
Reversible acute renal failure induced by losartan in a renal transplant recipient. |
| Authors: |
Ostermann, M.; Goldsmith, D. J.; Doyle, T.; Kingswood, J. C.; Sharpstone, P. |
| Publisher Information: |
British Medical Journal Publishing Group |
| Publication Year: |
1997 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Research Article |
| Description: |
A 56-year-old man who received a live-related renal transplant in 1988 was started in 1995 on the selective angiotensin II antagonist losartan (Dupont-Merke) to treat worsening hypertension. Two months later because of pulmonary oedema, loop diuretics were started. Within two weeks, serum creatinine had increased from 245 to 571 mumol/l, and the patient became oliguric. A systolic bruit was noted over the graft. Renal angiography showed a 90% stenosis of the transplant renal artery. Losartan was withdrawn, with prompt improvement in renal function. A successful percutaneous transluminal angioplasty performed a few days later resulted in further improvement in renal function accompanied by a significant diuresis. |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://pmj.bmj.com/cgi/content/short/73/856/105; http://dx.doi.org/10.1136/pgmj.73.856.105 |
| DOI: |
10.1136/pgmj.73.856.105 |
| Availability: |
http://pmj.bmj.com/cgi/content/short/73/856/105; https://doi.org/10.1136/pgmj.73.856.105 |
| Rights: |
Copyright (C) 1997, The Fellowship of Postgraduate Medicine |
| Accession Number: |
edsbas.8AE60CC6 |
| Database: |
BASE |