| Title: |
The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample |
| Authors: |
Moran, Rachel; Beatty, Stephen; Stack, Jim; O'Halloran, Aisling M; Feeney, Joanne; Akuffo, Kwadwo O; Peto, Tunde; Kenny, Rose Anne; Nolan, John M |
| Source: |
Moran, R, Beatty, S, Stack, J, O'Halloran, A M, Feeney, J, Akuffo, K O, Peto, T, Kenny, R A & Nolan, J M 2018, 'The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population-Based Sample', Current eye research, vol. 43, no. 3, pp. 383-390. https://doi.org/10.1080/02713683.2017.1403633 |
| Publication Year: |
2018 |
| Collection: |
Queen's University Belfast: Research Portal |
| Subject Terms: |
Journal Article |
| Description: |
PURPOSE: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and self-reported prevalence of age-related macular degeneration (AMD). MATERIAL AND METHODS: Data collected from a nationally representative prospective cohort study of community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography, and retinal photographs were graded using a version of the AMD International Classification and Grading System. Consumption of supplements containing L and/or Z and/or MZ was recorded as supplement use. Four groups were identified: Group 1 (n = 24): AMD-afflicted and correctly aware; Group 2 (n = 264): AMD-afflicted but unaware; Group 3 (n = 41): AMD-free and incorrectly believed that they were afflicted with the condition; Group 4 (n = 4094): AMD-free and correctly self-reported absence of AMD. RESULTS: Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs, 288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history and age, the relationship between grading-confirmed AMD and plasma L was positive and significant (p < 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ± 0.132 µmol) and Group 4 (mean = 0.2040 ± 0.121 µmol/L) were significantly lower than Group 1 (mean = 0.4691 ± 0.0.372 µmol/L) and Group 3 (mean = 0.3176 ± 0.0.235 µmol/L). Supplement use was reported by 41.7% and 17.1% of participants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4, respectively. CONCLUSION: A belief that one suffers from AMD, whether justified or not, is associated with supplement use and with higher plasma concentrations of L. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
0271-3683; 1460-2202 |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29172786; info:eu-repo/semantics/altIdentifier/pissn/0271-3683; info:eu-repo/semantics/altIdentifier/eissn/1460-2202 |
| DOI: |
10.1080/02713683.2017.1403633 |
| Availability: |
https://pure.qub.ac.uk/en/publications/4db0c6fc-45e9-4240-96f4-6b54f9de4907; https://doi.org/10.1080/02713683.2017.1403633; https://pureadmin.qub.ac.uk/ws/files/148630363/The_Relationship_Between_Plasma_Concentrations_of_Lutein_and_Zeaxanthin_with_Self_Reported_and_Actual_Prevalence_of_AMD_in_an_Irish_Population_Based.pdf |
| Rights: |
info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.8AFEE21B |
| Database: |
BASE |