| Title: |
Diagnostic accuracy of research criteria for prodromal frontotemporal dementia |
| Authors: |
Benussi, Alberto; Premi, Enrico; Grassi, Mario; Alberici, Antonella; Cantoni, Valentina; Gazzina, Stefano; Archetti, Silvana; Gasparotti, Roberto; Fumagalli, Giorgio G.; Bouzigues, Arabella; Russell, Lucy L; Samra, Kiran; Cash, David M.; Bocchetta, Martina; Todd, Emily G.; Convery, Rhian S.; Swift, Imogen; Sogorb-Esteve, Aitana; Heller, Carolin; Van Swieten, John C.; Jiskoot, Lize C; Seelaar, Harro; Sanchez-Valle, Raquel; Moreno, Fermin; Laforce, Robert Jr; Graff, Caroline; Synofzik, Matthis; Galimberti, Daniela; Rowe, James B.; Masellis, Mario; Tartaglia, Maria Carmela; Finger, Elizabeth; Vandenberghe, Rik; De Mendonca, Alexandre; Tiraboschi, Pietro; Butler, Chris R.; Santana, Isabel; Gerhard, Alexander; Le Ber, Isabelle; Pasquier, Florence; Ducharme, Simon; Levin, Johannes; Sorbi, Sandro; Otto, Markus; Padovani, Alessandro; Rohrer, Jonathan D.; Borroni, Barbara |
| Contributors: |
Université de Lille; Inserm; CHU Lille; Università degli Studi di Brescia = University of Brescia UniBs; Azienda Socio Sanitaria Territoriale Spedali Civili di Brescia Brescia; Università degli Studi di Pavia Italia = University of Pavia Italy = Université de Pavie Italie UNIPV; Università degli Studi di Trento = University of Trento UNITN; UCL Institute of Neurology, Queen Square London; UK Dementia Research Institute UK DRI; Erasmus University Medical Center Rotterdam Erasmus MC; Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS; Hospital Universitario Donostia San Sebastian, Spain HUD; BioDonostia Health Research Institute = Instituto de Investigación Sanitaria Biodonostia; Université Laval Québec ULaval; Karolinska Institutet Science Park; Karolinska University Hospital Solna, Sweden KUH; Eberhard Karls Universität Tübingen = University of Tübingen; German Research Center for Neurodegenerative Diseases - Deutsches Zentrum für Neurodegenerative Erkrankungen DZNE; Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico; Università degli Studi di Milano = University of Milan UNIMI; Cambridge University Hospitals - NHS CUH; University of Cambridge UK CAM; Sunnybrook Health Sciences Centre Toronto Sunnybrook; Tanz Center Research in Neurodegenerative Diseases Toronto; University of Western Ontario UWO; Catholic University of Leuven = Katholieke Universiteit Leuven KU Leuven; University Hospitals Leuven Leuven; Faculdade de Medicina Lisboa; Fondazione IRCCS Istituto Neurologico "Carlo Besta"; University of Oxford; Imperial College London; Universidade de Coimbra = University of Coimbra Portugal UC; Hospitais da Universidade de Coimbra H.U.C.; Universität Duisburg-Essen = University of Duisburg-Essen Essen; Wolfson Molecular Imaging Centre WMIC; Institut du Cerveau = Paris Brain Institute ICM; CHU Pitié-Salpêtrière AP-HP; Lille Centre of Excellence for Neurodegenerative Disorders = Centre d'excellence des maladies neurodégénératives de Lille LiCEND; Lille Neurosciences & Cognition (LilNCog) - U 1172; McConnell Brain Imaging Centre MNI; McGill University = Université McGill Montréal, Canada; Ludwig Maximilian University Munich = Ludwig Maximilians Universität München LMU; Munich Cluster for systems neurology Munich SyNergy; Università degli Studi di Firenze = University of Florence = Université de Florence UniFI; Fondazione Don Carlo Gnocchi; Universität Ulm - Ulm University Ulm, Allemagne; Dementia Research Centre London DRC |
| Publisher Information: |
BioMed Central |
| Publication Year: |
2025 |
| Collection: |
LillOA (Lille Open Archive - Université de Lille) |
| Subject Terms: |
Prodromal; MCBMI; Frontotemporal dementia; Diagnostic criteria; Diagnostic accuracy |
| Description: |
Background : The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls. Methods : A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment. Results : The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001). Conclusions : The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD. ; 16 |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf |
| Language: |
English |
| Relation: |
Alzheimer's Research and Therapy; Alzheimers Res Ther; http://hdl.handle.net/20.500.12210/114852 |
| Availability: |
https://hdl.handle.net/20.500.12210/114852 |
| Rights: |
Attribution 3.0 United States ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.8B3C5051 |
| Database: |
BASE |