| Title: |
The RNA of Maize Chlorotic Mottle Virus, an Obligatory Component of Maize Lethal Necrosis Disease, Is Translated via a Variant Panicum Mosaic Virus-Like Cap-Independent Translation Element |
| Authors: |
Carino, Elizabeth J.; Scheets, Kay; Miller, W. Allen |
| Contributors: |
Sandri-Goldin, Rozanne M.; Plant Sciences Institute, Iowa State University; Iowa State University Graduate Minority Assistance Progam; HHS | NIH | National Institute of General Medical Sciences |
| Source: |
Journal of Virology ; volume 94, issue 22 ; ISSN 0022-538X 1098-5514 |
| Publisher Information: |
American Society for Microbiology |
| Publication Year: |
2020 |
| Description: |
In the past decade, maize lethal necrosis disease has caused massive crop losses in East Africa. It has also emerged in China and parts of South America. Maize chlorotic mottle virus (MCMV) infection is required for this disease. While some tolerant maize lines have been identified, there are no known resistance genes that confer immunity to MCMV. In order to improve resistance strategies against MCMV, we focused on how the MCMV genome is translated, the first step of gene expression by all positive-strand RNA viruses. We identified a structure (cap-independent translation element) in the 3′ untranslated region of the viral RNA genome that allows the virus to usurp a host translation initiation factor, eIF4E, in a way that differs from host mRNA interactions with the translational machinery. This difference indicates eIF4E may be a soft target for engineering of—or breeding for—resistance to MCMV. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1128/jvi.01005-20 |
| DOI: |
10.1128/JVI.01005-20 |
| Availability: |
https://doi.org/10.1128/jvi.01005-20; https://journals.asm.org/doi/pdf/10.1128/JVI.01005-20 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ ; https://journals.asm.org/non-commercial-tdm-license |
| Accession Number: |
edsbas.8B5B5BEB |
| Database: |
BASE |