| Title: |
Time-dependent vaccine efficacy estimation quantified by a mathematical model |
| Authors: |
Loria, Jennifer; Albani, Vinícius Viana Luiz; Coutinho, Francisco Antonio Bezerra; Covas, Dimas Tadeu; Struchiner, Claudio José; Zubelli, Jorge Passamani; Massad, Eduardo |
| Contributors: |
Instituto de Matemática Pura e Aplicada; (UCR) Universidad de Costa Rica; (UFSC) Universidade Federal de Santa Catarina; (USP) Universidade de São Paulo; (FGV) Fundação Getulio Vargas; Khalifa University; (HC/HCFMUSP) Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Covas, Dimas Tadeu|:Diretor|:Diretoria Técnica; Brasil; Diretoria Técnica |
| Publication Year: |
2023 |
| Description: |
In this paper we calculate the variation of the estimated vaccine efficacy (VE) due to the time-dependent force of infection resulting from the difference between the moment the Clinical Trial (CT) begins and the peak in the outbreak intensity. Using a simple mathematical model we tested the hypothesis that the time difference between the moment the CT begins and the peak in the outbreak intensity determines substantially different values for VE. We exemplify the method with the case of the VE efficacy estimation for one of the vaccines against the new coronavirus SARS-CoV-2. ; (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico ; (FAPERJ) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro ; (FAPESC) Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina ; (UCR) Universidad de Costa Rica ; Yes |
| Document Type: |
article in journal/newspaper |
| File Description: |
e0285466 |
| Language: |
English |
| Relation: |
PloS One; https://repositorio.butantan.gov.br/handle/butantan/4985; 18; v. 18, n. 5, e0285466, maio. 2023; 2023 May; 18(5):e0285466; BR78.1; IBProd |
| DOI: |
10.1371/journal.pone.0285466 |
| Availability: |
https://repositorio.butantan.gov.br/handle/butantan/4985; https://doi.org/10.1371/journal.pone.0285466 |
| Rights: |
open |
| Accession Number: |
edsbas.8B696719 |
| Database: |
BASE |