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Gender Differences in Ventricular Tachyarrhythmia Events in the Raid Trial

Title: Gender Differences in Ventricular Tachyarrhythmia Events in the Raid Trial
Authors: Kutyifa, V; Vloka, M E; Huang, D T; Varanasi, S N; Shinn, T S; Attari, M; Shah, A H; Lessmeier, T J; Musat, D L; Rosenthal, L S; Sakaguchi, S; Sun, A Y; McNitt, S; Schleede, S; Schuger, Claudio; Natalie, A; McPherson, C A; Ziv, O; Daubert, J P; Zareba, W
Source: Cardiology Meeting Abstracts
Publisher Information: Henry Ford Health Scholarly Commons
Publication Year: 2019
Collection: Henry Ford Health System Scholarly Commons
Description: Background: Women have previously shown to be at a lower risk of ventricular tachyarrhythmia (VT) events in ICD trials, however, more contemporary data on the risk of VT/VF by gender, utilizing uniform, novel ICD programming are lacking. Objective: We aimed to assess gender differences in VT/VF events treated with ATP or treated with shock, and all-cause mortality in the RAID trial. Methods: The RAID trial enrolled high-risk ICD patients with ischemic or non-ischemic cardiomyopathy randomized to ranolazine or placebo. ICD programming was pre-specified with VT zone 190-220 bpm with 1 ATP and shocks and VF zone >220 bpm with shocks. Gender differences in VT/VF requiring ATP or shock were evaluated using Kaplan-Meier analysis and Cox models in an intention to treat analysis. All VT/VF episodes were centrally adjudicated. Results: There were 186 women (18%) out of 1012 subjects enrolled in RAID trial. Women were younger (61 vs. 65 years, p
Document Type: text
Language: unknown
Relation: https://scholarlycommons.henryford.com/cardiology_mtgabstracts/169
Availability: https://scholarlycommons.henryford.com/cardiology_mtgabstracts/169
Accession Number: edsbas.8B7316B6
Database: BASE