| Title: |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals |
| Authors: |
Lee, JJ; Wedow, R; Okbay, A; Kong, E; Maghzian, O; Zacher, M; Nguyen-Viet, TA; Bowers, P; Sidorenko, J; Linnér, R; Fontana, MA; Kundu, T; Lee, C; Li, H; Li, R; Royer, R; Timshel, PN; Walters, RK; Willoughby, EA; Yengo, L; Team, 23andMe Research; Consortium), COGENT (Cognitive Genomics; Consortium, Social Science Genetic Association; Alver, M; Bao, Y; Clark, DW; Day, FR; Furlotte, NA; Joshi, PK; Kemper, KE; Kleinman, A; Langenberg, C; Mägi, R; Trampush, JW; Verma, SS; Wu, Y; Lam, M; Zhao, JH; Zheng, Z; Boardman, JD; Campbell, H; Freese, J; Harris, KM; Hayward, C; Herd, P; Kumari, M; Lencz, T; Luan, J; Malhotra, AK; Metspalu, A; Milani, L; Ong, KK; Perry, JRB; Porteous, DJ; Ritchie, MD; Smart, MC; Smith, BH; Tung, JY; Wareham, NJ; Wilson, JF; Beauchamp, JP; Conley, DC; Esko, T; Lehrer, SF; Magnusson, PKE; Oskarsson, S; Pers, TH; Robinson, MR; Thom, K; Watson, C; Chabris, CF; Meyer, MN; Laibson, DI; Yang, J; Johannesson, M; Koellinger, PD; Turley, P; Visscher, PM; Benjamin, DJ; Cesarini, D |
| Publisher Information: |
Nature Publishing Group |
| Publication Year: |
2018 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
| Document Type: |
article in journal/newspaper |
| Language: |
unknown |
| DOI: |
10.1038/s41588-018-0147-3 |
| Availability: |
https://doi.org/10.1038/s41588-018-0147-3; https://ora.ox.ac.uk/objects/uuid:60aef5be-468b-47e9-a561-4302e40b2ae0 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.8BA98568 |
| Database: |
BASE |