| Title: |
Gas chromatography – Sensor system aids diagnosis of inflammatory bowel disease, and separates Crohn’s from ulcerative colitis, in children |
| Authors: |
Slater, Rachael; Tharmaratnam, Kukatharmini; Belnour, Salma; Auth, Marcus Karl-Heinz; Muhammed, Rafeeq; Spray, Christine; Wang, Duolao; de Lacy Costello, Ben; García-Fiñana, Marta; Allen, Stephen; Probert, Chris |
| Publisher Information: |
MDPI |
| Publication Year: |
2024 |
| Collection: |
University of the West of England, Bristol: UWE Research Repository |
| Description: |
The diagnosis of inflammatory bowel disease (IBD) in children and the need to distinguish between subtypes (Crohn’s disease (CD) and ulcerative colitis (UC)) requires lengthy investigative and invasive procedures. Non-invasive, rapid, and cost-effective tests to support these diagnoses are needed. Faecal volatile organic compounds (VOCs) are distinctive in IBD. VOC profiles can be rapidly determined using a gas chromatography–sensor device (OdoReader©). In an inception-cohort of children presenting with suspected IBD, we directly compared the diagnostic fidelity of faecal calprotectin (FCP, a non-specific protein marker of intestinal inflammation) with OdoReader© VOC profiles of children subsequently diagnosed with IBD with matched controls diagnosed with other gastrointestinal conditions. The OdoReader© was 82% (95% confidence interval 75–89%) sensitive and 71% (61–80%) specific but did not outperform FCP (sensitivity 93% (77–99%) and specificity 86% (67–96%); 250 µg/g FCP cut off) in the diagnosis of IBD from other gastrointestinal conditions when validated in a separate sample from the same cohort. However, unlike FCP and better than other similar technologies, the OdoReader© could distinguish paediatric CD from UC (up to 88% (82–93%) sensitivity and 80% (71–89%) specificity in the validation set) and justifies further validation in larger studies. A non-invasive test based on VOCs could help streamline and limit invasive investigations in children. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://uwe-repository.worktribe.com/file/12792096/1/Gas%20chromatography%20%E2%80%93%20Sensor%20system%20aids%20diagnosis%20of%20inflammatory%20bowel%20disease,%20and%20separates%20Crohn%E2%80%99s%20from%20ulcerative%20colitis,%20in%20children; https://uwe-repository.worktribe.com/output/12792096 |
| DOI: |
10.3390/s24155079 |
| Availability: |
https://uwe-repository.worktribe.com/output/12792096; https://doi.org/10.3390/s24155079 |
| Rights: |
openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.8C21CB6C |
| Database: |
BASE |