| Title: |
Amyloid-β predominant Alzheimer’s disease neuropathologic change |
| Authors: |
Kovacs, Gabor G; Katsumata, Yuriko; Wu, Xian; Aung, Khine Zin; Fardo, David W; Forrest, Shelley L; Bowen, James D; Crane, Paul K; Jarvik, Gail P; Keene, C Dirk; Larson, Eric B; McCormick, Wayne C; McCurry, Susan M; Mukherjee, Shubhabrata; Kowall, Neil W; McKee, Ann C; Stern, Robert A; Baldwin, Clinton T; Farrer, Lindsay A; Jun, Gyungah; Lunetta, Kathryn L; Honig, Lawrence S; Vonsattel, Jean Paul; Williamson, Jennifer; Small, Scott; Barral, Sandra; Reitz, Christiane; Vardarajan, Badri N; Mayeux, Richard; Burke, James R; Hulette, Christine M; Welsh-Bohmer, Kathleen A; Gearing, Marla; Lah, James J; Levey, Allan I; Wingo, Thomas S; Apostolova, Liana G; Farlow, Martin R; Ghetti, Bernardino; Saykin, Andrew J; Spina, Salvatore; Faber, Kelley M; Foroud, Tatiana M; Albert, Marilyn S; Lyketsos, Constantine G; Troncoso, Juan C; Frosch, Matthew P; Green, Robert C; Growdon, John H; Hyman, Bradley T; Tanzi, Rudolph E; Potter, Huntington; Dickson, Dennis W; Ertekin-Taner, Nilufer; Graff-Radford, Neill R; Parisi, Joseph E; Petersen, Ronald C; Boeve, Bradley F; Allen, Mariet; Carrasquillo, Minerva M; Younkin, Steven G; Duara, Ranjan; Buxbaum, Joseph D; Goate, Alison M; Sano, Mary; Masurkar, Arjun V; Wisniewski, Thomas; Bigio, Eileen H; Mesulam, Marsel; Weintraub, Sandra; Vassar, Robert; Kaye, Jeffrey A; Quinn, Joseph F; Woltjer, Randall L; Barnes, Lisa L; Yu, Lei; Evans, Denis A; Henderson, Victor; Fallon, Kenneth B; Harrell, Lindy E; Marson, Daniel C; Roberson, Erik D; DeCarli, Charles; Jin, Lee-Way; Olichney, John M; Kim, Ronald; LaFerla, Frank M; Monuki, Edwin; Head, Elizabeth; Sultzer, David; Geschwind, Daniel H; Vinters, Harry V; Chesselet, Marie-Francoise; Galasko, Douglas R; Brewer, James B; Boxer, Adam; Karydas, Anna; Kramer, Joel H; Miller, Bruce L; Rosen, Howard J |
| Source: |
Brain, vol 148, iss 2 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2025 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 42 Health Sciences (for-2020); 52 Psychology (for-2020); Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) (rcdc); Dementia (rcdc); Neurosciences (rcdc); Neurodegenerative (rcdc); Brain Disorders (rcdc); Acquired Cognitive Impairment (rcdc); Genetics (rcdc); Aging (rcdc); Alzheimer's Disease (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); Neurological (hrcs-hc); Humans (mesh); Alzheimer Disease (mesh); Female (mesh); Male (mesh); Aged (mesh); Amyloid beta-Peptides (mesh); Aged; 80 and over (mesh); tau Proteins (mesh); Plaque; Amyloid (mesh); Neurofibrillary Tangles (mesh); Brain (mesh); Apolipoproteins E (mesh); Tauopathies (mesh); Sorting Nexins (mesh) |
| Subject Geographic: |
401 - 407 |
| Description: |
Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer's Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt4h71524s; https://escholarship.org/uc/item/4h71524s; https://escholarship.org/content/qt4h71524s/qt4h71524s.pdf |
| DOI: |
10.1093/brain/awae325 |
| Availability: |
https://escholarship.org/uc/item/4h71524s; https://escholarship.org/content/qt4h71524s/qt4h71524s.pdf; https://doi.org/10.1093/brain/awae325 |
| Rights: |
CC-BY |
| Accession Number: |
edsbas.8C2A75D9 |
| Database: |
BASE |