A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery.
| Title: | A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA delivery. |
|---|---|
| Authors: | Gooding, M; Adigbli, D; Edith Chan, AW; Melander, RJ; Macrobert, AJ; Selwood, DL |
| Source: | Chem Biol Drug Des , 84 (1) pp. 24-35. (2014) |
| Publication Year: | 2014 |
| Collection: | University College London: UCL Discovery |
| Subject Terms: | biophysical chemistry; carbohydrate; chemical biology; lipid; nucleic acid; RNAi and antisense techniques |
| Description: | A wider application of siRNA and miRNA based therapeutics is restricted by the currently available delivery systems. We have designed a new type of small molecule carrier (SMoC) system for siRNA modelled to interact with cell surface proteoglycans. This bifurcated SMoC has similar affinity for the model proteoglycan heparin to an equivalent polyarginine peptide and exhibits significant mRNA knockdown of protein levels comparable to lipofectamine and the previously reported linear SMoC. This article is protected by copyright. All rights reserved. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://discovery.ucl.ac.uk/id/eprint/1423601/1/cbdd12295.pdf; https://discovery.ucl.ac.uk/id/eprint/1423601/ |
| Availability: | https://discovery.ucl.ac.uk/id/eprint/1423601/1/cbdd12295.pdf; https://discovery.ucl.ac.uk/id/eprint/1423601/ |
| Rights: | open |
| Accession Number: | edsbas.8C4A27D2 |
| Database: | BASE |