| Title: |
The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: A Pilot Study |
| Authors: |
Brislane, Á; Jones, H; Holder, SM; Low, DA; Hopkins, ND |
| Publisher Information: |
Springer |
| Publication Year: |
2020 |
| Collection: |
Liverpool John Moores University: LJMU Research Online |
| Subject Terms: |
RC1200 Sports Medicine; RG Gynecology and obstetrics |
| Description: |
Purpose: The aim of this pilot study is to obtain estimates for the change in maternal cerebrovascular (primary) and offspring vascular structure (secondary) during healthy pregnancy that includes structured exercise. Methods: Eighteen pregnant women self-assigned to a moderate-intensity aerobic exercise intervention or a control group. Maternal cerebral blood flow (CBF) at the middle cerebral artery, cerebro- and peripheral-vascular function were assessed at the end of each trimester. Offspring carotid artery intima-media thickness (IMT) was measured within 12-weeks of birth. Results: For exploratory purposes, we performed statistical analysis to provide estimates of the change for primary and secondary outcome variables. Maternal CBF reduced (-8 cm/s-1 [-14 to -2]) with evidence of change to cerebral autoregulation (normalised gain: 0.12 %cm s-1 %.mmHg-1mm Hg/% [-0.18 to 0.40]) during pregnancy. Offspring carotid IMT was smaller in the exercise group (-0.04mm [-0.12-0.03]) compared to controls. Based upon this data, a sample size of 33 and 57 in each group are required for low frequency normalised gain and offspring IMT respectively. This would provide 90% power to detect statistically significant (P |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1933-7205 |
| Relation: |
https://researchonline.ljmu.ac.uk/id/eprint/13526/11/Brislane2021_Article_TheEffectOfExerciseDuringPregn.pdf; Brislane, Á, Jones, H, Holder, SM, Low, DA and Hopkins, ND (2020) The Effect of Exercise During Pregnancy on Maternal and Offspring Vascular Outcomes: A Pilot Study. Reproductive Sciences, 28. pp. 510-523. ISSN 1933-7205 |
| DOI: |
10.1007/s43032-020-00302-7 |
| Availability: |
https://researchonline.ljmu.ac.uk/id/eprint/13526/; https://researchonline.ljmu.ac.uk/id/eprint/13526/11/Brislane2021_Article_TheEffectOfExerciseDuringPregn.pdf; https://doi.org/10.1007/s43032-020-00302-7 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.8CC4031D |
| Database: |
BASE |