| Title: |
Feasibility of in vivo measurement of carotid wall shear rate using spiral Fourier velocity encoded MRI |
| Authors: |
Carvalho, Joao L. A.; Nielsen, Jon-Fredrik; Nayak, Krishna S. |
| Contributors: |
Magnetic Resonance Engineering Laboratory, Ming Hsieh Department of Electrical Engineering, University of Southern California, Los Angeles, California, USA; Functional MRI Laboratory, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA; Digital Signal Processing Group, Department of Electrical Engineering, University of BrasÍlia, BrasÍlia-DF, Brazil; Departamento de Engenharia ElÉtrica, Campus UniversitÁrio Darcy Ribeiro, Caixa Postal 4386, BrasÍlia-DF, Brazil 70919-970 |
| Publisher Information: |
Wiley Subscription Services, Inc., A Wiley Company |
| Publication Year: |
2010 |
| Collection: |
University of Michigan: Deep Blue |
| Subject Terms: |
Life and Medical Sciences; Imaging; Health Sciences |
| Description: |
Arterial wall shear stress is widely believed to influence the formation and growth of atherosclerotic plaque; however, there is currently no gold standard for its in vivo measurement. The use of phase contrast MRI has proved to be challenging due to partial-volume effects and inadequate signal-to-noise ratio at the high spatial resolutions that are required. This work evaluates the use of spiral Fourier velocity encoded MRI as a rapid method for assessing wall shear rate in the carotid arteries. Wall shear rate is calculated from velocity histograms in voxels spanning the blood/vessel wall interface, using a method developed by Frayne and Rutt (Magn Reson Med 1995;34:378–387). This study (i) demonstrates the accuracy of the velocity histograms measured by spiral Fourier velocity encoding in a pulsatile carotid flow phantom compared with high-resolution two-dimensional Fourier transform phase contrast, (ii) demonstrates the accuracy of Fourier velocity encoding–based shear rate measurements in a numerical phantom designed using a computational fluid dynamics simulation of carotid flow, and (iii) demonstrates in vivo measurement of regional wall shear rate and oscillatory shear index in the carotid arteries of healthy volunteers at 3 T. Magn Reson Med 63:1537–1547, 2010. © 2010 Wiley-Liss, Inc. ; Peer Reviewed ; http://deepblue.lib.umich.edu/bitstream/2027.42/75777/1/22325_ftp.pdf |
| Document Type: |
article in journal/newspaper |
| File Description: |
854323 bytes; 3118 bytes; application/pdf; text/plain |
| Language: |
unknown |
| Relation: |
http://hdl.handle.net/2027.42/75777; Magnetic Resonance in Medicine |
| DOI: |
10.1002/mrm.22325 |
| Availability: |
http://hdl.handle.net/2027.42/75777; https://doi.org/10.1002/mrm.22325 |
| Rights: |
IndexNoFollow |
| Accession Number: |
edsbas.8CDBC013 |
| Database: |
BASE |