| Title: |
Comparison of the Effect of Secondary Hyperparathyroidism Due to Vitamin D Deficiency on Bone with the Healthy Control Group ; D Vitamini Eksikliğine Bağlı Sekonder Hiperparatiroidizm’in Kemik Üzerine Etkisinin Sağlıklı Kontrol Grubu ile Karşılaştırılması |
| Authors: |
Demir, Hakan; Cihan, Cem; Gönüllü, Emre; Capoglu, Recayi; Yiğit, Merve; Aka, Bahaeddin Umur; Harmantepe, Ahmet Tarık |
| Source: |
Volume: 7, Issue: 2134-140 ; 2587-1641 ; Journal of Biotechnology and Strategic Health Research |
| Publisher Information: |
Deneysel, Biyoteknolojik, Klinik ve Stratejik Sağlık Araştırmaları Derneği |
| Publication Year: |
2023 |
| Collection: |
DergiPark Akademik (E-Journals) |
| Subject Terms: |
Vitamin D; secondary hyperparathyroidism; osteoporosis; D vitamini; sekonder hiperparatiroidizm; osteoporoz; Clinical Sciences (Other); Klinik Tıp Bilimleri (Diğer) |
| Description: |
Aim: In healthy individuals, to demonstrate that adequate vitamin D status protects against osteoporosis by improving bone mineral density and reducing the risk of fractures.Material and method: Fifty patients with high parathyroid hormone secondary to low vitamin D level and 50 patients with normal parathyroid hormones were included in the study as the control group.Results: Of the 50 patients with secondary hyperparathyroidism due to vitamin D deficiency included in the study, 45 (90%) were female and 5 (10%) were male. In the control group with normal parathyroid hormone, 44 (88%) were female and 6% (12%) were male. The median age in the hyperparathyroid group was 70.5 (66-73) and in the parathyroid hormone normal group it was 71 (69-73). This median mean age was significant (p 0.004).In the group with secondary hyperparathyroidism; The median PTH value was 99.5 (66-205.9) and 49.8 (27-61.5) in the control group, with a significant difference (p < 0.001). While 25-Hydroxy Vitamin D level was 10.73 (4.64-34.1) in the group with normal parathyroid hormone level, it was 18.63 (6.21-65.1). This created a significant difference in both groups (p < 0.001). According to the results of bone densitometry in the hyperparathyroidic and control groups. no significant difference was found between bone mineral density (BMD). 0.92 (0.66 – 1134), 0.93 (0.75 – 1293), (p0.095).However, for the femur, the results in T and Z scores were significant (p 0.027- p 0.027), whereas for the supine (spine), no significant difference was observed between the T and Z scores (p 0.358- p 0.265).Conclusion: . Especially when the vitamin D level falls below 10 ng/mL, PTH begins to respond. Beyond these observations, a normal serum 25(OH)D concentration is particularly important in preventing femur fractures, but its significance for vertebral fractures is unclear. ; Giriş: Sağlıklı bireylerde yeterli D vitamini durumunun, kemik mineral yoğunluğunu iyileştirerek ve kırık riskini azaltarak, osteoporoza karşı koruduğunu ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://dergipark.org.tr/tr/download/article-file/3252635; https://dergipark.org.tr/tr/pub/bshr/issue/79733/1324716 |
| DOI: |
10.34084/bshr.1324716 |
| Availability: |
https://dergipark.org.tr/tr/pub/bshr/issue/79733/1324716; https://doi.org/10.34084/bshr.1324716 |
| Accession Number: |
edsbas.8D5BD446 |
| Database: |
BASE |