Effect of homotaurine in patients with cognitive impairment: Results from an Italian observational retrospective study
| Title: | Effect of homotaurine in patients with cognitive impairment: Results from an Italian observational retrospective study |
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| Authors: | Martorana A.; Motta C.; Koch G.; Massaia M.; Mondino S.; Raniero I.; Vacca A.; Di Lorenzo F.; Cavallo G.; Oddenino E.; Pavanelli E.; Maniscalco M.; Montano V.; Mastropietro A.; Bellia N. C.; Ciravegna E.; La Rocca M.; Vitale E.; Lorico F.; Zacchettin B.; Scalise A.; Codemo A.; Gabelli C.; Spano M.; Poli S.; Panuccio D.; Bruno P.; Alfieri P.; Ruggiero R.; Cursi F.; Levi della Vida G. |
| Contributors: | Martorana, A.; Motta, C.; Koch, G.; Massaia, M.; Mondino, S.; Raniero, I.; Vacca, A.; Di Lorenzo, F.; Cavallo, G.; Oddenino, E.; Pavanelli, E.; Maniscalco, M.; Montano, V.; Mastropietro, A.; Bellia, N. C.; Ciravegna, E.; La Rocca, M.; Vitale, E.; Lorico, F.; Zacchettin, B.; Scalise, A.; Codemo, A.; Gabelli, C.; Spano, M.; Poli, S.; Panuccio, D.; Bruno, P.; Alfieri, P.; Ruggiero, R.; Cursi, F.; Levi Della Vida, G. |
| Publication Year: | 2018 |
| Collection: | Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: | Alzheimer’s disease; Homotaurine; Mild cognitive impairment |
| Description: | Background & Aims: This observational retrospective study aimed at evaluating the effects of one-year administration of homotaurine (tramiprosate) in a sample patients presenting with symptoms of mild cognitive impairment. Methods: Patient’s demographic data and medical history are reported. Each patient performed brain imaging and neuropsychological assessment to reach the diagnosis. Each patient assumed 100 mg total dose of homotaurine/day. The evolution of the cognitive decline over time was evaluated my means of the Mini Mental State Examination (MMSE). Results: 245 patients from 28 different centres in Italy were recruited. Significant improvements from baseline expressed as mean MMSE total score were observed in patients with aMCI at months 8 and 12 (p < 0.0001), and in those with mMCI at month 4 (p < 0.05). Conclusions: Administration of homotaurine revealed beneficial effects in our sample population of MCI patients. Our results indicate clearly that homotaurine may well be considered as a potential symptomatic treatment for cognitive symptoms. Further research is however needed to clarify whether this compound could influence the progression of cognitive decline. |
| Document Type: | article in journal/newspaper |
| File Description: | ELETTRONICO |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/wos/WOS:000430699300003; volume:66; issue:1; firstpage:15; lastpage:20; numberofpages:6; journal:JOURNAL OF GERONTOLOGY AND GERIATRICS; https://hdl.handle.net/11392/2505187 |
| Availability: | https://hdl.handle.net/11392/2505187 |
| Accession Number: | edsbas.8D610132 |
| Database: | BASE |