| Title: |
Effect of intraperitoneal magnesium sulfate in the prevention of postoperative pain in daycare laparoscopic cholecystectomy – A prospective randomized controlled trial |
| Authors: |
Sravanthi, Gorle Chaitanya; Abuji, Kishore; Soni, Shiv Lal; Nagaraj, Satish Subbiah; Sharma, Akhilesh; Jafra, Anudeep; Tandup, Cherring; Kurdia, Kailash Chand; Dahiya, Divya |
| Source: |
Indian Journal of Pharmacology ; volume 55, issue 3, page 174-178 ; ISSN 0253-7613 |
| Publisher Information: |
Medknow |
| Publication Year: |
2023 |
| Description: |
This study evaluated the efficacy of intraperitoneal magnesium sulfate (MgSO 4 ) in preventing postoperative pain after elective laparoscopic cholecystectomy (LC). It is a prospective, double-blinded, placebo-controlled, randomized trial which included 64 patients who underwent LC. Patients were equally randomized into Groups A and B. MgSO 4 and normal saline were instilled in subdiaphragmatic space in Groups A and B, respectively, after creating pneumoperitoneum and before starting dissection. The Visual analogue Scale (VAS) was used to determine postoperative pain. Patients who received intraperitoneal MgSO 4 had lower average VAS scores for the first 6 h postoperatively, and also, the time for the requirement of first analgesic was longer (3.6 ± 0.4 vs. 2.3 ± 1.0 h). The incidence of vomiting and the requirement for rescue antiemetic was also lower in Group A. Intraperitoneal instillation of MgSO 4 reduces postoperative pain and vomiting following elective LC without incurring additional side effects. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.4103/ijp.ijp_827_22 |
| Availability: |
https://doi.org/10.4103/ijp.ijp_827_22; https://journals.lww.com/10.4103/ijp.ijp_827_22 |
| Accession Number: |
edsbas.8DE1DAA3 |
| Database: |
BASE |