| Title: |
The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas. |
| Authors: |
Forshell, LP; Li, Y; Forshell, TZ; Rudelius, M; Nilsson, L; Keller, U; Nilsson, J |
| Contributors: |
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Allgemeine Pathologie und Pathologische Anatomie |
| Publication Year: |
2011 |
| Collection: |
Munich University of Technology (TUM): mediaTUM |
| Subject Terms: |
info:eu-repo/classification/ddc |
| Description: |
The Pim kinases are weak oncogenes. However, when co-expressed with a strong oncogene, such as c-Myc, Pim kinases potentiate the oncogenic effect resulting in an acceleration of tumorigenesis. In this study we show that the least studied Pim kinase, Pim-3, is encoded by a gene directly regulated by c-Myc via binding to one of the conserved E-boxes within the Pim3 gene. Accordingly, lymphomas arising in Myc-transgenic mice and Burkitt lymphoma cell lines exhibit elevated levels of Pim-3. Interestingly, inhibition of Pim kinases by a novel pan-Pim kinase inhibitor, Pimi, in Myc-induced lymphoma results in cell death that appears independent of caspases. The data indicate that Pim kinase inhibition could be a viable treatment strategy in certain human lymphomas that rely on Pim-3 kinase expression. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://mediatum.ub.tum.de/1099940 |
| Availability: |
https://mediatum.ub.tum.de/1099940 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.8DF82BCC |
| Database: |
BASE |