| Title: |
Pulmonary Function Trajectories in People with HIV: Analysis of the Pittsburgh HIV Lung Cohort. |
| Authors: |
Konstantinidis, Ioannis; Qin, Shulin; Fitzpatrick, Meghan; Kessinger, Cathy; Gentry, Heather; McMahon, Deborah; Weinman, R Dawn; Tien, Phyllis; Huang, Laurence; McCormack, Meredith; Barjaktarevic, Igor; Reddy, Divya; Foronjy, Robert; Lazarous, Deepa; Cohen, Mardge H; McKay, Heather; Adimora, Adaora A; Moran, Caitlin; Fischl, Margaret A; Dionne-Odom, Jodie; Stosor, Valentina; Drummond, M Bradley; Cribbs, Sushma K; Kunisaki, Ken; Rinaldo, Charles; Morris, Alison; Nouraie, S Mehdi |
| Source: |
Annals of the American Thoracic Society, vol 19, iss 12 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2022 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3207 Medical Microbiology (for-2020); 32 Biomedical and Clinical Sciences (for-2020); Lung (rcdc); HIV/AIDS (rcdc); Infectious Diseases (rcdc); Respiratory (hrcs-hc); 3 Good Health and Well Being (sdg); Humans (mesh); Endothelin-1 (mesh); Lung (mesh); Forced Expiratory Volume (mesh); Vital Capacity (mesh); Lung Diseases (mesh); HIV Infections (mesh); Dyspnea (mesh); Cytokines (mesh); human immunodeficiency virus; pulmonary function; group-based trajectory modeling; 3201 Cardiovascular medicine and haematology (for-2020); 3202 Clinical sciences (for-2020) |
| Time: |
2013 - 2020 |
| Description: |
Rationale: Human immunodeficiency virus (HIV) infection is associated with chronic lung disease and impaired pulmonary function; however, longitudinal pulmonary function phenotypes in HIV are undefined. Objectives: To identify pulmonary function trajectories, their determinants, and outcomes. Methods: We used data from participants with HIV in the Pittsburgh HIV Lung Cohort with three or more pulmonary function tests between 2007 and 2020. We analyzed post-bronchodilator forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC, and diffusing capacity of the lung for carbon monoxide (DlCO) using group-based trajectory modeling to identify subgroups of individuals whose measurements followed a similar pattern over time. We examined the association between participant characteristics and trajectories using multivariable logistic regression. In exploratory adjusted analyses restricted to individuals with available plasma cytokine data, we investigated the association between 18 individual standardized cytokine concentrations and trajectories. We compared mortality, dyspnea prevalence, respiratory health status, and 6-minute-walk distance between phenotypes. Results: A total of 265 participants contributed 1,606 pulmonary function measurements over a median follow-up of 8.1 years. We identified two trajectories each for FEV1 and FVC: "low baseline, slow decline" and "high baseline, rapid decline." There were three trajectory groups for FEV1/FVC: "rapid decline," "moderate decline," and "slow decline." Finally, we identified two trajectories for DlCO: "baseline low" and "baseline high." The low baseline, slow decline FEV1 and FVC, rapid decline, and moderate decline FEV1/FVC, and baseline low DlCO phenotypes were associated with increased dyspnea prevalence, worse respiratory health status, and decreased 6-minute-walk distance. The baseline low DlCO phenotype was also associated with worse mortality. Current smoking and pack-years of smoking were associated with the adverse FEV1, ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt6j20f9t5; https://escholarship.org/uc/item/6j20f9t5; https://escholarship.org/content/qt6j20f9t5/qt6j20f9t5.pdf |
| DOI: |
10.1513/annalsats.202204-332oc |
| Availability: |
https://escholarship.org/uc/item/6j20f9t5; https://escholarship.org/content/qt6j20f9t5/qt6j20f9t5.pdf; https://doi.org/10.1513/annalsats.202204-332oc |
| Rights: |
public |
| Accession Number: |
edsbas.8E163F83 |
| Database: |
BASE |