| Title: |
The role of kidney dysfunction in COVID-19 and the influence of age |
| Authors: |
La Porta E.; Baiardi P.; Fassina L.; Faragli A.; Perna S.; Tovagliari F.; Tallone I.; Talamo G.; Secondo G.; Mazzarello G.; Esposito V.; Pasini M.; Lupo F.; Deferrari G.; Bassetti M.; Esposito C. |
| Contributors: |
E. La Porta; P. Baiardi; L. Fassina; A. Faragli; S. Perna; F. Tovagliari; I. Tallone; G. Talamo; G. Secondo; G. Mazzarello; V. Esposito; M. Pasini; F. Lupo; G. Deferrari; M. Bassetti; C. Esposito |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2022 |
| Collection: |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: |
Settore MED/49 - Scienze Tecniche Dietetiche Applicate |
| Description: |
COVID-19 is strongly influenced by age and comorbidities. Acute kidney injury (AKI) is a frequent finding in COVID-19 patients and seems to be associated to mortality and severity. On the other hand, the role of kidney dysfunction in COVID-19 is still debated. We performed a retrospective study in a cohort of 174 hospitalized COVID-19 patients in Italy from March 3rd to May 21st 2020, to investigate the role of kidney dysfunction on COVID-19 severity and mortality. Moreover, we examined in depth the relationship between kidney function, age, and progression of COVID-19, also using different equations to estimate the glomerular filtration rate (GFR). We performed logistic regressions, while a predictive analysis was made through a machine learning approach. AKI and death occurred respectively in 10.2% and 19.5%, in our population.The major risk factors for mortality in our cohort were age [adjusted HR, 6.2; 95% confidence interval (CI) 1.8–21.4] and AKI [3.36 (1.44–7.87)], while, in these relationships, GFR at baseline mitigated the role of age. The occurrence of AKI was influenced by baseline kidney function, D-dimer, procalcitonin and hypertension. Our predictive analysis for AKI and mortality reached an accuracy of ≥ 94% and ≥ 91%, respectively. Our studyscales down the role of kidney function impairment on hospital admission , especially in elderly patients. BIS-1 formula demonstrated a worse performance to predict the outcomes in COVID-19 patients when compared with MDRD and CKD-EPI. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35606394; info:eu-repo/semantics/altIdentifier/wos/WOS:000799388600030; volume:12; issue:1; firstpage:1; lastpage:9; numberofpages:9; journal:SCIENTIFIC REPORTS; https://hdl.handle.net/2434/956239 |
| DOI: |
10.1038/s41598-022-12652-0 |
| Availability: |
https://hdl.handle.net/2434/956239; https://doi.org/10.1038/s41598-022-12652-0 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.8E431B11 |
| Database: |
BASE |