| Title: |
Brain Metabolism and Amyloid Load in Individuals with Subjective Cognitive Decline or Pre-Mild Cognitive Impairment |
| Authors: |
Tondo G.; Boccalini C.; Vanoli E. G.; Presotto L.; Muscio C.; Ciullo V.; Banaj N.; Piras F.; Filippini G.; Tiraboschi P.; Tagliavini F.; Frisoni G. B.; Cappa S. F.; Spalletta G.; Perani D. |
| Contributors: |
Tondo, G.; Boccalini, C.; Vanoli, E. G.; Presotto, L.; Muscio, C.; Ciullo, V.; Banaj, N.; Piras, F.; Filippini, G.; Tiraboschi, P.; Tagliavini, F.; Frisoni, G. B.; Cappa, S. F.; Spalletta, G.; Perani, D. |
| Publisher Information: |
Lippincott Williams and Wilkins |
| Publication Year: |
2022 |
| Description: |
Background and ObjectiveThis was a multicenter study aimed at investigating the characteristics of cognitive decline, neuropsychiatric symptoms, and brain imaging in individuals with subjective cognitive decline (SCD) and subtle cognitive decline (pre-mild cognitive impairment [pre-MCI]).MethodsData were obtained from the Network-AD project (NET-2011-02346784). The included participants underwent baseline cognitive and neurobehavioral evaluation, FDG-PET, and amyloid PET. We used principal component analysis (PCA) to identify independent neuropsychological and neuropsychiatric dimensions and their association with brain metabolism.ResultsA total of 105 participants (SCD = 49, pre-MCI = 56) were included. FDG-PET was normal in 45% of participants and revealed brain hypometabolism in 55%, with a frontal-like pattern as the most frequent finding (28%). Neuropsychiatric symptoms emerging from the Neuropsychiatric Inventory and the Starkstein Apathy Scale were highly prevalent in the whole sample (78%). An abnormal amyloid load was detected in the 18% of the participants who underwent amyloid PET (n = 60). PCA resulted in 3 neuropsychological factors: (1) executive/visuomotor, correlating with hypometabolism in frontal and occipital cortices and basal ganglia; (2) memory, correlating with hypometabolism in temporoparietal regions; and (3) visuospatial/constructional, correlating with hypometabolism in frontoparietal cortices. Two factors emerged from the neuropsychiatric PCA: (1) affective, correlating with hypometabolism in orbitofrontal and cingulate cortex and insula; (2) hyperactive/psychotic, correlating with hypometabolism in frontal, temporal, and parietal regions.DiscussionFDG-PET evidence suggests either normal brain function or different patterns of brain hypometabolism in SCD and pre-MCI. These results indicate that SCD and pre-MCI represent heterogeneous populations. Different neuropsychological and neuropsychiatric profiles emerged, which correlated with neuronal dysfunction in specific brain regions. ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35487700; info:eu-repo/semantics/altIdentifier/wos/WOS:000827766500019; volume:99; issue:3; firstpage:258; lastpage:269; numberofpages:12; journal:NEUROLOGY; https://hdl.handle.net/20.500.11768/132860 |
| DOI: |
10.1212/WNL.0000000000200351 |
| Availability: |
https://hdl.handle.net/20.500.11768/132860; https://doi.org/10.1212/WNL.0000000000200351 |
| Accession Number: |
edsbas.8E4A5854 |
| Database: |
BASE |