| Title: |
Derivation of Indices of Cognitive Change Among Hispanic Adults and Elders |
| Authors: |
Duff, Kevin; Miller, Justin B.; Cobos, Kim; Rodrigues, Jessica; O’Bryant, Sid E.; O'Bryant, Sid; Yaffe, Kristine; Toga, Arthur; Rissman, Robert; Johnson, Leigh; Braskie, Meredith; King, Kevin; Hall, James R.; Petersen, Melissa; Palmer, Raymond; Barber, Robert; Shi, Yonggang; Zhang, Fan; Nandy, Rajesh; McColl, Roderick; Mason, David; Christian, Bradley; Phillips, Nicole; Large, Stephanie; Lee, Joe; Vardarjaran, Badri; Rivera Mindt, Monica; Cheema, Amrita; Barnes, Lisa; Mapstone, Mark; Cohen, Annie; Kind, Amy; Okonkwo, Ozioma; Vintimilla, Raul; Zhou, Zhengyang; Donohue, Michael; Raman, Rema; Borzage, Matthew; Mielke, Michelle; Ances, Beau; Babulal, Ganesh; Llibre-Guerra, Jorge; Hill, Carl; Vig, Rocky |
| Source: |
JAMA Network Open ; volume 7, issue 9, page e2431180 ; ISSN 2574-3805 |
| Publisher Information: |
American Medical Association (AMA) |
| Publication Year: |
2024 |
| Description: |
Importance Determining the influence of race and ethnicity on change in cognitive test performance has significant implications for clinical practice and research in populations at risk for Alzheimer disease. Objective To evaluate the significance of race and ethnicity in predicting longitudinal cognitive test performance and to develop models to support evidence-based practice. Design, Setting, and Participants This prognostic study included baseline and 24-month follow-up data that were obtained from the Health and Aging Brain Study—Health Disparities (HABS-HD) study, an ongoing longitudinal observational study of aging and dementia in a multiracial, multiethnic cohort. Participants included community-dwelling adults and elders living in the Dallas and Fort Worth metropolitan area who were Hispanic and non-Hispanic adults older than the age of 50 years and were cognitively unimpaired. Exposure The primary exposure of interest was time, measured in months. Main Outcomes and Measures Demographic variables included age, sex, education, and race and ethnicity. Cognitive domains included attention and working memory, processing speed, language, memory, and executive functioning. Linear regression models predicted follow-up performance from baseline performance and demographic variables for 13 commonly used neuropsychological tests. Follow-up testing was the primary outcome for all domains. Raw scores from 13 standardized tests were used for analyses. Results This study included 799 adults who were cognitively unimpaired (352 Hispanic individuals [44.1%]; 447 non-Hispanic individuals [55.9%]; 524 female [65.6%]; mean [SD] age, 65.4 [8.1] years). In the regression models, all 13 follow-up scores were significantly predicted from their respective baseline scores and demographic variables. Baseline performance and education were the most consistent predictors of follow-up scores, contributing to all 13 models. Age was significantly associated with follow-up in 11 models, and sex was significant in 5 models. Race and ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1001/jamanetworkopen.2024.31180 |
| Availability: |
https://doi.org/10.1001/jamanetworkopen.2024.31180; https://jamanetwork.com/journals/jamanetworkopen/articlepdf/2823093/duff_2024_oi_240938_1724699266.43725.pdf |
| Accession Number: |
edsbas.8E6101A1 |
| Database: |
BASE |