| Title: |
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination |
| Authors: |
Liew, F; Talwar, S; Cross, A; Willett, BJ; Scott, S; Logan, N; Siggins, MK; Swieboda, D; Sidhu, JK; Efstathiou, C; Moore, SC; Noursadeghi, M; Olanipekun, M; Osagie, A; Palmarini, M; Palmieri, C; Paxton, WA; Pollakis, G; Price, N; Rambaut, A; Robertson, DL; Russell, CD; Sancho-Shimizu, V; Sands, C; Scott, JT; Sigfrid, L; Solomon, T; Sriskandan, S; Stuart, D; Summers, C; Nolan, CM; Swann, OV; Takats, Z; Takis, P; Tedder, RS; Thomson, EC; Zambon, M; Drake, TM; Davis, C; Mohamed, N; Nunag, J; King, C; Thompson, AAR; Rowland-Jones, SL; Docherty, AB; Chalmers, JD; Ho, LP; Horsley, A; Raman, B; Poinasamy, K; Marks, M; Kon, OM; Howard, L; Wootton, DG; Dunachie, S; Quint, JK; Evans, RA; Wain, LV; Fontanella, S; de Silva, TI; Ho, A; Harrison, E; Baillie, JK; Semple, MG; Brightling, C; Thwaites, RS; Turtle, L; Openshaw, PJM; Alex, B; Andrikopoulos, P; Bach, B; Barclay, WS; Bogaert, D; Chand, M; Chechi, K; Cooke, GS; da Silva Filipe, A; de Silva, T; dos Santos Correia, G; Dumas, ME; Dunning, J; Fletcher, T; Green, CA; Greenhalf, W; Griffin, J; Gupta, RK; Harrison, EM; Ho, AYW; Holden, K; Horby, PW; Ijaz, S; Khoo, S; Klenerman, P; Law, A; Lewis, M; Liggi, S; Lim, WS; Maslen, L; Mentzer, AJ; Merson, L; Meynert, AM |
| Contributors: |
ISARIC4C Investigators; PHOSP-COVID collaborative group |
| Publisher Information: |
Elsevier |
| Publication Year: |
2023 |
| Collection: |
Brunel University London: Brunel University Research Archive (BURA) |
| Subject Terms: |
COVID-19; SARS-CoV-2 immunity; convalescent; nasal antibody; mucosal immunity; vaccination; SARS-CoV-2 variants |
| Description: |
Data sharing statement This is an Open Access article under the CC BY 4.0 license The ISARIC4C protocol, data sharing and publication policy are available at https://isaric4c.net. ISARIC4C's Independent Data and Material Access Committee welcomes applications for access to data and materials (https://isaric4c.net). The PHOSP-COVID protocol, consent form, definition and derivation of clinical characteristics and outcomes, training materials, regulatory documents, information about requests for data access, and other relevant study materials are available online: https://phosp.org/resource/. Access to these materials can be granted by contacting phosp@leicester.ac.uk and Phospcontracts@leicester.ac.uk. All data used in this study is available within ODAP and accessible under reasonable request. Data access criteria and information about how to request access is available online: https://phosp.org/resource/. If criteria are met and a request is made, access can be gained by signing the eDRIS user agreement. ; Supplementary data are available online at https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00584-9/fulltext#supplementaryMaterial . ; Copyright © 2022 The Author(s). Background: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. Methods: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. Findings: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
1 - 14; Electronic |
| Language: |
English |
| Relation: |
eBioMedicine; 104402; https://bura.brunel.ac.uk/handle/2438/26835; https://doi.org/10.1016/j.ebiom.2022.104402 |
| DOI: |
10.1016/j.ebiom.2022.104402 |
| Availability: |
https://bura.brunel.ac.uk/handle/2438/26835; https://doi.org/10.1016/j.ebiom.2022.104402 |
| Rights: |
Copyright © 2022 The Author(s). Published by Elsevier B.V. This is an Open Access article under the CC BY 4.0 license ; https://creativecommons.org/licenses/by/4.0/ ; The Author(s) |
| Accession Number: |
edsbas.8E62F633 |
| Database: |
BASE |