| Title: |
The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network. |
| Authors: |
Hossain, Mohammad S; Commons, Robert J; Douglas, Nicholas M; Thriemer, Kamala; Alemayehu, Bereket H; Amaratunga, Chanaki; Anvikar, Anupkumar R; Ashley, Elizabeth A; Asih, Puji BS; Carrara, Verena I; Lon, Chanthap; D'Alessandro, Umberto; Davis, Timothy ME; Dondorp, Arjen M; Edstein, Michael D; Fairhurst, Rick M; Ferreira, Marcelo U; Hwang, Jimee; Janssens, Bart; Karunajeewa, Harin; Kiechel, Jean R; Ladeia-Andrade, Simone; Laman, Moses; Mayxay, Mayfong; McGready, Rose; Moore, Brioni R; Mueller, Ivo; Newton, Paul N; Thuy-Nhien, Nguyen T; Noedl, Harald; Nosten, Francois; Phyo, Aung P; Poespoprodjo, Jeanne R; Saunders, David L; Smithuis, Frank; Spring, Michele D; Stepniewska, Kasia; Suon, Seila; Suputtamongkol, Yupin; Syafruddin, Din; Tran, Hien T; Valecha, Neena; Van Herp, Michel; Van Vugt, Michele; White, Nicholas J; Guerin, Philippe J; Simpson, Julie A; Price, Ric N |
| Publisher Information: |
PUBLIC LIBRARY SCIENCE |
| Publication Year: |
2020 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
BACKGROUND: There is a high risk of Plasmodium vivax parasitaemia following treatment of falciparum malaria. Our study aimed to quantify this risk and the associated determinants using an individual patient data meta-analysis in order to identify populations in which a policy of universal radical cure, combining artemisinin-based combination therapy (ACT) with a hypnozoitocidal antimalarial drug, would be beneficial. METHODS AND FINDINGS: A systematic review of Medline, Embase, Web of Science, and the Cochrane Database of Systematic Reviews identified efficacy studies of uncomplicated falciparum malaria treated with ACT that were undertaken in regions coendemic for P. vivax between 1 January 1960 and 5 January 2018. Data from eligible studies were pooled using standardised methodology. The risk of P. vivax parasitaemia at days 42 and 63 and associated risk factors were investigated by multivariable Cox regression analyses. Study quality was assessed using a tool developed by the Joanna Briggs Institute. The study was registered in the International Prospective Register of Systematic Reviews (PROSPERO: CRD42018097400). In total, 42 studies enrolling 15,341 patients were included in the analysis, including 30 randomised controlled trials and 12 cohort studies. Overall, 14,146 (92.2%) patients had P. falciparum monoinfection and 1,195 (7.8%) mixed infection with P. falciparum and P. vivax. The median age was 17.0 years (interquartile range [IQR] = 9.0-29.0 years; range = 0-80 years), with 1,584 (10.3%) patients younger than 5 years. 2,711 (17.7%) patients were treated with artemether-lumefantrine (AL, 13 studies), 651 (4.2%) with artesunate-amodiaquine (AA, 6 studies), 7,340 (47.8%) with artesunate-mefloquine (AM, 25 studies), and 4,639 (30.2%) with dihydroartemisinin-piperaquine (DP, 16 studies). 14,537 patients (94.8%) were enrolled from the Asia-Pacific region, 684 (4.5%) from the Americas, and 120 (0.8%) from Africa. At day 42, the cumulative risk of vivax parasitaemia following treatment of P. falciparum was ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| ISSN: |
1549-1277 |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4660443/1/The%20risk%20of%20Plasmodium%20vivax%20parasitaemia%20after%20P.%20falciparum%20malaria%20An%20individual%20patient%20data%20meta-analysis%20from%20the%20Worl.pdf; Hossain, Mohammad SORCID logo; Commons, Robert JORCID logo; Douglas, Nicholas MORCID logo; Thriemer, KamalaORCID logo; Alemayehu, Bereket H; Amaratunga, Chanaki; Anvikar, Anupkumar RORCID logo; Ashley, Elizabeth AORCID logo; Asih, Puji BSORCID logo; Carrara, Verena IORCID logo; +38 more.Lon, ChanthapORCID logo; D'Alessandro, Umberto ORCID logo; Davis, Timothy MEORCID logo; Dondorp, Arjen MORCID logo; Edstein, Michael D; Fairhurst, Rick M; Ferreira, Marcelo UORCID logo; Hwang, JimeeORCID logo; Janssens, Bart; Karunajeewa, Harin; Kiechel, Jean R; Ladeia-Andrade, Simone; Laman, MosesORCID logo; Mayxay, Mayfong; McGready, RoseORCID logo; Moore, Brioni RORCID logo; Mueller, IvoORCID logo; Newton, Paul NORCID logo; Thuy-Nhien, Nguyen TORCID logo; Noedl, Harald; Nosten, FrancoisORCID logo; Phyo, Aung PORCID logo; Poespoprodjo, Jeanne RORCID logo; Saunders, David L; Smithuis, FrankORCID logo; Spring, Michele DORCID logo; Stepniewska, KasiaORCID logo; Suon, Seila; Suputtamongkol, YupinORCID logo; Syafruddin, Din; Tran, Hien T; Valecha, Neena; Van Herp, Michel; Van Vugt, Michele; White, Nicholas JORCID logo; Guerin, Philippe JORCID logo; Simpson, Julie AORCID logo; and Price, Ric NORCID logo (2020) The risk of Plasmodium vivax parasitaemia after P. falciparum malaria: An individual patient data meta-analysis from the WorldWide Antimalarial Resistance Network. PLOS MEDICINE, 17 (11). e1003393-. ISSN 1549-1277 DOI:10.1371/journal.pmed.1003393 |
| DOI: |
10.1371/journal.pmed.1003393 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4660443/; https://doi.org/10.1371/journal.pmed.1003393 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.8EC1A666 |
| Database: |
BASE |