Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort
| Title: | Exploring Sex Differences in Outcomes of Dual Antiplatelet Therapy for Patients With Noncardioembolic Mild-to-Moderate Ischemic Stroke or High-Risk Transient Ischemic Attack: A Propensity-Matched Analysis of the READAPT Study Cohort |
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| Authors: | Foschi, Matteo; D'Anna, Lucio; De Matteis, Eleonora; De Santis, Federico; Romoli, Michele; Tassinari, Tiziana; Saia, Valentina; Cenciarelli, Silvia; Bedetti, Chiara; Padiglioni, Chiara; Censori, Bruno; Puglisi, Valentina; Vinciguerra, Luisa; Guarino, Maria; Barone, Valentina; Zedde, Marialuisa; Grisendi, Ilaria; Diomedi, Marina; Bagnato, Maria Rosaria; Petruzzellis, Marco; Mezzapesa, Domenico Maria; Di Viesti, Pietro; Inchingolo, Vincenzo; Cappellari, Manuel; Zivelonghi, Cecilia; Candelaresi, Paolo; Andreone, Vincenzo; Rinaldi, Giuseppe; Bavaro, Alessandra; Cavallini, Anna; Moraru, Stefan; Piscaglia, Maria Grazia; Terruso, Valeria; Mannino, Marina; Pezzini, Alessandro; Frisullo, Giovanni; Muscia, Francesco; Paciaroni, Maurizio; Mosconi, Maria Giulia; Zini, Andrea; Leone, Ruggiero; Palmieri, Carmela; Cupini, Letizia Maria; Marcon, Michela; Tassi, Rossana; Sanzaro, Enzo; Papiri, Giuli; Paci, Cristina; Viticchi, Giovanna; Orsucci, Daniele; Falcou, Anne; Beretta, Simone; Tarletti, Roberto; Nencini, Patrizia; Rota, Eugenia; Sepe, Federica Nicoletta; Ferrandi, Delfina; Caputi, Luigi; Volpi, Gino; La Spada, Salvatore; Beccia, Mario; Rinaldi, Claudia; Mastrangelo, Vincenzo; Di Blasio, Francesco; Invernizzi, Paolo; Pelliccioni, Giuseppe; De Angelis, Maria Vittoria; Bonanni, Laura; Ruzza, Giampietro; Caggia, Emanuele Alessandro; Russo, Monia; Tonon, Agnese; Acciarri, Maria Cristina; Anticoli, Sabrina; Roberti, Cinzia; Manobianca, Giovanni; Scaglione, Gaspare; Pistoia, Francesca; Fortini, Alberto; De Boni, Antonella; Sanna, Alessandra; Chiti, Alberto; Barbarini, Leonardo; Caggiula, Marcella; Masato, Maela; Del Sette, Massimo; Passarelli, Francesco; Bongioanni, Maria Roberta; De Michele, Manuela; Ricci, Stefano; Ornello, Raffaele; Sacco, Simona |
| Contributors: | Foschi, Matteo; D'Anna, Lucio; De Matteis, Eleonora; De Santis, Federico; Romoli, Michele; Tassinari, Tiziana; Saia, Valentina; Cenciarelli, Silvia; Bedetti, Chiara; Padiglioni, Chiara; Censori, Bruno; Puglisi, Valentina; Vinciguerra, Luisa; Guarino, Maria; Barone, Valentina; Zedde, Marialuisa; Grisendi, Ilaria; Diomedi, Marina; Bagnato, Maria Rosaria; Petruzzellis, Marco; Mezzapesa, Domenico Maria; Di Viesti, Pietro; Inchingolo, Vincenzo; Cappellari, Manuel; Zivelonghi, Cecilia; Candelaresi, Paolo; Andreone, Vincenzo; Rinaldi, Giuseppe; Bavaro, Alessandra; Cavallini, Anna; Moraru, Stefan; Piscaglia, Maria Grazia; Terruso, Valeria; Mannino, Marina; Pezzini, Alessandro; Frisullo, Giovanni; Muscia, Francesco; Paciaroni, Maurizio; Mosconi, Maria Giulia; Zini, Andrea; Leone, Ruggiero; Palmieri, Carmela; Cupini, Letizia Maria; Marcon, Michela; Tassi, Rossana; Sanzaro, Enzo; Papiri, Giuli; Paci, Cristina; Viticchi, Giovanna; Orsucci, Daniele; Falcou, Anne; Beretta, Simone; Tarletti, Roberto; Nencini, Patrizia; Rota, Eugenia; Sepe, Federica Nicoletta; Ferrandi, Delfina; Caputi, Luigi; Volpi, Gino; La Spada, Salvatore; Beccia, Mario; Rinaldi, Claudia; Mastrangelo, Vincenzo; Di Blasio, Francesco; Invernizzi, Paolo; Pelliccioni, Giuseppe; De Angelis, Maria Vittoria; Bonanni, Laura; Ruzza, Giampietro; Caggia, Emanuele Alessandro; Russo, Monia; Tonon, Agnese; Acciarri, Maria Cristina; Anticoli, Sabrina; Roberti, Cinzia; Manobianca, Giovanni; Scaglione, Gaspare; Pistoia, Francesca; Fortini, Alberto; De Boni, Antonella; Sanna, Alessandra; Chiti, Alberto; Barbarini, Leonardo; Caggiula, Marcella; Masato, Maela; Del Sette, Massimo; Passarelli, Francesco; Bongioanni, Maria Roberta; De Michele, Manuela; Ricci, Stefano; Ornello, Raffaele; Sacco, Simona |
| Publication Year: | 2025 |
| Collection: | Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: | hemorrhage; ischemic attack; transient; ischemic stroke; sex; women |
| Description: | BACKGROUND: Sex may impact clinical outcomes in patients with stroke treated with dual antiplatelet therapy (DAPT). We aimed to investigate the sex differences in the short-term outcomes of DAPT within a real-world population of patients with noncardioembolic mild-to-moderate ischemic stroke or high-risk transient ischemic attack. METHODS: We performed a propensity score-matched analysis from a prospective multicentric cohort study (READAPT [Real-Life Study on Short-Term Dual Antiplatelet Treatment in Patients With Ischemic Stroke or Transient Ischemic Attack]) by including patients with noncardioembolic mild-to-moderate stroke (National Institutes of Health Stroke Scale score of 0-10) or high-risk transient ischemic attack (age, blood pressure, clinical features, duration of transient ischemic attack, presence of diabetes [ABCD2] ≥4) who initiated DAPT within 48 hours of symptom onset. The primary effectiveness outcome was the 90-day risk of new ischemic stroke or other vascular events. The secondary effectiveness outcomes were the 90-day modified Rankin Scale score ordinal shift, vascular and all-cause mortality, and 24-hour early neurological improvement or deterioration. The safety outcomes included the 90-day risk of moderate-to-severe and any bleeding, symptomatic intracranial hemorrhage, and 24-hour hemorrhagic transformation. Outcomes were compared between sexes using Cox and generalized ordinal logistic regression analyses, along with calculating risk differences and ratios. RESULTS: From 2278 patients in the READAPT study cohort, we included 1643 mild-to-moderate strokes or high-risk transient ischemic attacks treated with DAPT (mean age, 69.8±12.0 years; 34.3% women). We matched 531 women and men. The 90-day risk of new ischemic stroke or other vascular events was significantly lower among women than men (hazard ratio, 0.53 [95% CI, 0.28-0.99]; P=0.039). There were no significant differences in secondary effectiveness outcomes. The 90-day risk of safety outcomes was extremely low and did not differ ... |
| Document Type: | article in journal/newspaper |
| File Description: | STAMPA |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39648888; info:eu-repo/semantics/altIdentifier/wos/WOS:001413403800001; volume:56; issue:2; firstpage:305; lastpage:317; numberofpages:13; journal:STROKE; https://hdl.handle.net/11392/2596293 |
| DOI: | 10.1161/STROKEAHA.124.049210 |
| Availability: | https://hdl.handle.net/11392/2596293; https://doi.org/10.1161/STROKEAHA.124.049210; https://www.ahajournals.org/doi/10.1161/STROKEAHA.124.049210 |
| Rights: | info:eu-repo/semantics/openAccess ; license:PUBBLICO - Pubblico con Copyright ; license uri:iris.PUB02 |
| Accession Number: | edsbas.8EF487AC |
| Database: | BASE |