| Title: |
The prognostic role of fatigue, depression and anxiety on postoperative outcomes after pancreatectomy for pancreatic cancer. A prospective observational study (FAT-PRO study) |
| Authors: |
Tuveri M.; Perri G.; Marinelli V.; Lionetto G.; Addari L.; Cova C.; Del Piccolo L.; Salvia R.; Bassi C. |
| Contributors: |
Tuveri, M.; Perri, G.; Marinelli, V.; Lionetto, G.; Addari, L.; Cova, C.; Del Piccolo, L.; Salvia, R.; Bassi, C. |
| Publisher Information: |
Elsevier B.V. |
| Publication Year: |
2022 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Anxiety; Depression; Fatigue; Pancreatic cancer; Pancreatic surgery |
| Description: |
Objectives: This study aims to assess the prevalence of preoperative fatigue, depression and anxiety among patients undergoing pancreatic surgery for pancreatic cancer (PC), and possible relationship with postoperative outcomes. Methods: Prospective data from 162 consecutive patients undergoing pancreatectomy for PC at a third-level referral centers for pancreatic surgery were collected. All patients preoperatively completed four questionnaires assessing depression (PHQ-9), anxiety (STAI-Y2), chronic illness fatigue (FACIT-F) and cancer therapy fatigue (FACT-G). Results: Forty patients (25%) where in the first quartile for chronic illness (FACIT-F ≤34) and/or cancer therapy (FACT-G ≤78) fatigue, 26 patients (16%) met the criteria for major depression (PHQ-9 ≥10) and 34 patients (21%) had anxiety symptoms (STAI-Y2 ≥40). Cancer therapy fatigue was significantly associated with higher rates of morbidity (70% vs 49%), major morbidity (Clavien-Dindo ≥3) (28% vs 11%), post-pancreatectomy hemorrhage (18% vs 4%), pulmonary complications (20% vs 9%) and mortality (8% vs null) (all P ≤ 0.01). Major depression was associated with higher rates of post-pancreatectomy hemorrhage and readmission (23% vs 5%). Multivariable logistic regression analysis of preoperative factors confirmed diabetes (OR 2.71, 95%CI 1.01–7.20; P = 0.04), ASA score ≥3 (OR 4.12, 95%CI 1.52–11.21; P < 0.01) and cancer therapy fatigue (OR 2.95, 95%CI 1.01–8.74; P = 0.04) to be independent predictors of major morbidity. Conclusions: Higher levels of fatigue (in particular cancer therapy fatigue) strongly correlates with worse postoperative outcomes. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/WOS:000923934600025; volume:22; issue:7; firstpage:1035; lastpage:1040; numberofpages:6; journal:PANCREATOLOGY; https://hdl.handle.net/11577/3576374 |
| DOI: |
10.1016/j.pan.2022.10.001 |
| Availability: |
https://hdl.handle.net/11577/3576374; https://doi.org/10.1016/j.pan.2022.10.001 |
| Accession Number: |
edsbas.8EFF4747 |
| Database: |
BASE |